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Cold Spring Harbor Protocols highlights reliable methods for gene and protein analyses

This month's release of Cold Spring Harbor Protocols highlights methods for creating and detecting specific proteins, as well as for characterizing the activities of specific genes during embryonic development. Two of the methods are freely available online.

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1. Cold Spring Harbor Protocols features methods for visualizing protein dynamics
   01-02-2008 · EurekAlert!
   The January 2008 issue of Cold Spring Harbor Protocols highlights methods that permit scientists to observe protein dynamics in chromosomes and embryos.
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2. A rainbow of methods promises insights into biological processes and diseases
   05-01-2007 · EurekAlert!
   This month's release of Cold Spring Harbor Protocols features freely available methods for marking molecules to identify gene alterations and metabolic shifts.
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3. A classic method for modeling skin cancer is featured in Cold Spring Harbor Protocols
   09-04-2007 · EurekAlert!
   This month's release of Cold Spring Harbor Protocols includes free access to a protocol for generating mice with squamous cell carcinoma (SCC), one of the most common types of skin cancer. It also includes free access to an efficient method for testing individuals for specific DNA variations called SNPs (single-nucleotide polymorphisms), which will be useful for identifying individuals with disease-related mutations.
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4. Bioinformatics-related methods are featured in Cold Spring Harbor Protocols
   07-02-2007 · EurekAlert!
   This month's release of Cold Spring Harbor Protocols highlights two articles that discuss the principles and applications of cutting-edge bioinformatics software programs.
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5. Plants, plasmids and possibilities -- Methods permit functional gene studies in plants
   12-01-2006 · EurekAlert!
   Decaffeinated coffee plants, pest-resistant cotton, and Vitamin A-producing rice varieties have all been developed by introducing genes into plants. Scientists also create modified plants to identify and characterize the functions of specific genes. The current issue of Cold Spring Harbor Protocols -- released online today -- includes a set of techniques for the creation of transgenic plants.
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6. RNA-based methods for developmental studies are featured in Cold Spring Harbor Protocols
   02-01-2008 · EurekAlert!
   This month's issue of Cold Spring Harbor Protocols highlights two methods to understand developmental processes in plants and flies. Both methods involve work with RNA and are freely accessible on the Web site for Cold Spring Harbor Protocols.
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7. Cost-effective method for gene silencing is featured in Cold Spring Harbor Protocols
   08-01-2007 · EurekAlert!
   The August, 2007 issue of Cold Spring Harbor Protocols includes a cost-effective approach for generating silencing RNAs, called esiRNAs, to efficiently target virtually any gene in mammalian cells.
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8. Cold Spring Harbor Protocols highlights a method that captures cell growth and activity
   11-01-2007 · EurekAlert!
   This month's issue of Cold Spring Harbor Protocols features a cutting-edge method that provides a snapshot of growth and activity patterns in mixed populations of cells. It also includes a related classic technique for the quantification of DNA and RNA in solutions.
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9. Cold Spring Harbor protocols features methods to understand embryos, clones, stem cells
   06-01-2007 · EurekAlert!
   Cloning, X-chromosome inactivation, stem cells, and embryogenesis are hot areas of research at the moment, and protocols featured in this month’s release of Cold Spring Harbor Protocols will aid these studies.
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10. Cold Spring Harbor scientists devise novel, low-cost method of sifting genome's high-value regions
    11-06-2007 · EurekAlert!
    Scientists at Cold Spring Harbor Laboratory have developed a new means of extracting and interpreting data from the human genome that is more powerful and more economical than methods currently employed. The new technology, called selective resequencing, promises to be a boon to many kinds of research, including efforts to comb vast stretches of the genome for mutant genes implicated in major diseases such as cancer and schizophrenia.
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