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Gene variation affects pain sensitivity and risk of chronic pain
10-22-2006 · EurekAlert!A new NIH-funded study shows that a specific gene variant in humans affects both sensitivity to short-term (acute) pain in healthy volunteers and the risk of developing chronic pain after one kind of back surgery. Blocking increased activity of this gene after nerve injury or inflammation in animals prevented development of chronic pain.
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Keywords: gene, variation, affects, pain, sensitivity, risk, chronic, affect
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- Molecule discovered to be key to pain sensitivity
10-22-2006 · EurekAlert!
Sensitivity to pain and the risk of developing chronic pain appear to be influenced by a molecule known to be required for the production of major neurotransmitters. In the November issue of Nature Medicine, an international research team describes this unexpected role for the molecule called BH4 and their findings that a particular set of variations in a human gene involved in synthesizing the molecule, appears to reduce pain sensitivity.
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- Vitamin D, variations in its receptor, and prostate cancer
03-19-2007 · EurekAlert!
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- Possible genetic link to schizophrenia identified
02-08-2007 · EurekAlert!
Several neurological and psychiatric disorders, including schizophrenia, are associated with changes in the brain that affect nerves that communicate with each other using dopamine. One protein that is crucial for dopamine-mediated neuronal communication in animals is DARPP-32. Now, researchers have shown that the gene that encodes DARPP-32 in humans exhibits genetic variation and that one particular variant is associated with increased performance in a number of cognitive tests and with an increased risk of schizophrenia.
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02-08-2007 · EurekAlert!
Most people inherit a version of a gene that optimizes their brain's thinking circuitry, yet also appears to increase risk for schizophrenia, a severe mental illness marked by impaired thinking. The seeming paradox emerged from the first study to explore the effects of variation in the human gene for a brain master switch, DARPP-32. The gene impacts the way two key brain regions exchange information, affecting a range of functions from general intelligence to attention.
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05-31-2007 · EurekAlert!
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- New treatment offers relief from chronic back pain
05-18-2007 · EurekAlert!
Chronic back pain is a condition that affects a significant part of the population, with patients falling into three major groups; those with herniated discs, spinal stenosis (a nerve affecting narrowing of the spinal cord), and complications from failed back surgery. Radiofrequency thermolesioning is a widespread treatment for chronic back pain, but because of its neurodestructive nature, it is often considered an unsuitable treatment.
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- Genetic mechanism helps explain chronic pain disorders
12-22-2006 · EurekAlert!
Researchers at the University of North Carolina at Chapel Hill have discovered that commonly occurring variations of a gene trigger a domino effect in chronic pain disorders. The finding might lead to more effective treatments for temporomandibular joint disorder (TMJD) and other chronic pain conditions.
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