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How do the rules of immunity change during chronic infections?

After an acute viral infection, some T cells generated to kill virus-infected cells remain on guard to establish long-term immunity. These so-called memory T cells, which derive from CD8 T cells, engage in a self-renewal process essential to their persistence. Now, a new study shows that the CD8 T cells produced to fight a chronic infection operate under an entirely different maintenance scheme than do the CD8 T cells that become memory T cells.

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Keywords: rules, immunity, change, chronic, infections, rule, infection

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   10-18-2007 · EurekAlert!
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