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Modified bone marrow cells can help recovery in an animal model of multiple sclerosis

04-09-2007 · EurekAlert!

A new study published in PLoS Medicine has shown that modified bone marrow cells can help recovery in an animal model of multiple sclerosis (MS).

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Keywords: modified, bone, marrow, cells, recovery, animal, model, multiple, sclerosis, cell, sclerosi

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    06-25-2007 · EurekAlert!
    Researchers have shown that bone marrow stem cells injected into a damaged inner ear can speed hearing recovery after partial hearing loss. The related report by Kamiya et al, "Mesenchymal stem cell transplantation accelerates hearing recovery through the repair of injured cochlear fibrocytes," appears in the July issue of The American Journal of Pathology.
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  2. Stroke victims may benefit from stem cell transplants
    01-28-2008 · EurekAlert!
    Two studies published in the current issue of Cell Transplantation examine the potential for cell transplants to benefit stroke victims. When injected into animal models and tracked via chemical tags and imaging, mensenchymal stem cells in one study, and bone marrow stromal cells in a second study, migrated within one to two weeks to affected brain areas and became therapeutically active. Both studies suggest that novel stem cell therapies can be developed.
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  3. Bone marrow cell transplants help nerve regeneration
    12-04-2007 · EurekAlert!
    Researchers inserted bone marrow-derived cells (BMCs) into 15mm silicon tubes and subsequently implanted into animal models at sites intended for nerve regeneration. When the BMCs were nourished with bioengineered additives -- such as growth factors and cell adhesion molecules -- the BMCs differentiated into cells with characteristics of Schwann cells -- a variety of neural cell providing insulating myelin around the axons of peripheral nerve cells. The work represents a further step in developing artificial nerves.
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  4. Penn Veterinary Medicine report new strategy to create genetically modified animals
    09-20-2007 · EurekAlert!
    Researchers at Penn Vet have demonstrated a new strategy for genetic modification of large animals by employing a virus that transfers genetic modifications to male reproductive cells, which passes naturally to offspring. Scientists at the Center for Animal Transgenesis and Germ Cell Research at Penn introduced adeno-associated virus to germline stem cells in goats and mice. AAV stably transduced male germ line stem cells and led to transgene transmission through the male germ line.
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  5. Stretching bone marrow stem cells pushes them towards becoming blood vessel
    10-23-2006 · EurekAlert!
    When stretched, a type of adult stem cell taken from bone marrow can be nudged towards becoming the type of tissue found in blood vessels, according to a new study by UC Berkeley bioengineers. The findings highlight the importance of mechanical forces in stem cell differentiation.
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  6. Oral drug sets a new survival standard for bone marrow cancer
    11-21-2007 · EurekAlert!
    Findings from two large, international clinical trials show "unprecedented" survival for patients with multiple myeloma, a blood cancer that occurs in the blood-making cells of bone marrow. The findings demonstrate that with Revlimid, an oral cancer drug, all measures of myeloma showed significant improvement in patients where previous treatments had failed.
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  7. Type of stem cell found to reside in transplanted lungs
    03-08-2007 · EurekAlert!
    A new study involving a type of stem cells from the lungs of transplant patients demonstrates for the first time that these progenitor cells reside in adult organs and are not derived from bone marrow, which leads to the possibility that the cells may be able to help with the rejection of donated organs and with various kinds of lung disease.
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  8. Natural, soy-based substance might help fight MS, Jefferson neuroscientists find
    12-12-2006 · EurekAlert!
    A natural substance made from soy appears to have amazing restorative powers when given to animals with a multiple sclerosis (MS)-like disease. Using an animal model of MS, neurologists at Jefferson Medical College found that giving a substance called Bowmann-Birk Inhibitor Concentrate (BBIC) dramatically improved the animals' ability to move and walk. The scientists say the treatment’s effects may be useful in conjunction with more mainstream therapies such as beta-interferon in helping patients with MS.
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    07-29-2007 · EurekAlert!
    Researchers at Johns Hopkins have found a way to overcome a major stumbling block to developing successful insulin-cell transplants for people with type I diabetes. They developed a new technique encapsulates the insulin-producing cells in magnetic capsules, using an FDA-approved iron compound with an off-label use, which can be tracked by magnetic resonance imaging (MRI). The product, tested in swine and diabetic mice, also simultaneously avoids rejection by the immune system, likely a major reason for transplant failure.
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    01-20-2008 · EurekAlert!
    Using embryonic stem cells from mice, UT Southwestern Medical Center researchers have prompted the growth of healthy -- and more importantly, functioning -- muscle cells in mice afflicted with a human model of Duchenne muscular dystrophy.
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