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Researchers find gene mutation that causes infertility in male mice
04-10-2007 · EurekAlert!Cornell University researchers have identified a mutation in a gene that causes male infertility in mice. Because this is the first time that a dominant mutation that leads specifically to infertility in a mammal has been discovered, the researchers say they can now look for similar mutations in the DNA of infertile men.
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Keywords: researchers, gene, mutation, causes, infertility, male, mice, researcher, cause
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- Rare mutation causes early heart disease and metabolic syndrome
03-01-2007 · EurekAlert!
Yale School of Medicine researchers have identified a rare defect in a single gene that poses a substantial risk for metabolic syndrome and early heart disease, the leading cause of death worldwide.
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- Fragile X retardation syndrome corrected in mice
12-19-2007 · EurekAlert!
Researchers working with mice have significantly alleviated a wide range of abnormalities due to fragile X syndrome by altering only a single gene, countering the effects of the fragile X mutation. They said their achievement offers the potential for treatment of the disorder, the most common form of inherited mental retardation and a leading identified genetic cause of autism. There is currently no treatment or therapy for fragile X syndrome, whose symptoms include mental retardation, epilepsy and abnormal body growth.
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- USC researchers explore genetic causes for male infertility
12-11-2007 · EurekAlert!
Researchers at the University of Southern California suggest epigenetics, or the way DNA is processed and expressed, may be the underlying cause for male infertility.
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- Enzyme regulates brain pathology induced by cocaine, stress
11-07-2007 · EurekAlert!
Researchers have uncovered a key genetic switch that chronic cocaine or stress influences to cause the brain to descend into a pathological state. In studies with mice they showed how chronic cocaine changes gene activity to enhance the addictive reward from the drug. And they showed similarly how chronic stress induces the same kinds of changes that hypersensitizes the brain, causing depression-like symptoms.
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- Linking 2 molecular pieces of the Alzheimer's puzzle
10-03-2007 · EurekAlert!
Researchers have uncovered a biological link between the protein whose mutation causes early-onset Alzheimer's disease and a gene variant linked to late-onset AD. The researchers said their finding could lead to new approaches to treating AD.
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- Lupus gene finding prompts call for more DNA samples
12-02-2007 · EurekAlert!
Wellcome Trust researchers have identified a key gene involved in the disease lupus, which affects around 50,000 people in the UK, mostly women. The lead researcher behind the study has called for more patients to volunteer DNA samples to enable them to further study the underlying causes of the disease.
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- How Rett Syndrome mutation targets the brain
10-18-2006 · EurekAlert!
Researchers have pinpointed why mutations that cause Rett Syndrome (RTT) -- among the leading causes of mental retardation in females -- specifically target the brain rather than other body tissues. They said their findings yield important insight into the origin and course of the disease.
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- Reactivated gene shrinks tumors, MIT study finds
01-24-2007 · Massachusetts Institute of Technology (MIT)
Many cancers arise due to defects in genes that normally suppress tumor growth. Now, for the first time, MIT researchers have shown that re-activating one of those genes in mice can cause tumors to shrink or disappear.
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- Gene malfunctions cause schizophrenia, depression symptoms in mice
05-02-2007 · EurekAlert!
Researchers have demonstrated for the first time that malfunction of a gene that had been associated with schizophrenia and depression does indeed cause symptoms of those disorders. They said their findings in mice offer a possible animal model for developing treatments for schizophrenia and depression.
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- Gene therapy for blindness clears hurdle in mice
03-14-2007 · EurekAlert!
University of Florida Genetics Institute researchers were able to use interfering RNA in experiments with mice to quiet a gene that plays a crucial role in a leading cause of inherited blindness. Disabling the gene is a step toward developing a gene therapy to treat people with retinitis pigmentosa, an inherited disease that attacks the light-sensing cells in the eye.
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