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A new study of living cells could revolutionize the way we test drugs
04-11-2007 · EurekAlert!Researchers have made a breakthrough by detecting the electrical equivalent of a living cell’s last gasp. The work takes them a step closer to both seeing the "heartbeat" of a living cell and a new way to test drugs.
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Keywords: study, living, cells, revolutionize, way, test, drugs, cell, drug
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- Discovery of an HIV inhibitor in human blood points to new drug class
04-19-2007 · EurekAlert!
A new study has pinpointed a natural ingredient of human blood that effectively blocks HIV-1, the virus predominantly responsible for human AIDS, from infecting immune cells and multiplying. The virus blocker might play a role in the progression of HIV to full-blown AIDS and -- because it works in a different way than existing antiretroviral inhibitors -- could lead to the development of another class of drugs in the fight against the pandemic disease.
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- New test predicts blood cancer's sensitivity to experimental cancer drug
01-22-2007 · EurekAlert!
A test developed by Dana-Farber Cancer Institute scientists is the first to identify which malignant blood cells are highly vulnerable to a promising type of experimental drugs that unleash pent-up "cell suicide" factors to destroy the cancer.
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- Soft-cell approach cuts animal tests
02-06-2007 · EurekAlert!
A new way to test the safety of the air we breathe is proving faster, cheaper and more humane than exposing laboratory animals to airborne chemical hazards, say UNSW scientists. Researchers at the university's Chemical Safety and Applied Toxicology Laboratories have developed an animal-free alternative that exposes living human cells to air pollutants inside a small chamber. The breakthrough could fast-track scientific understanding of the threat to human health posed by thousands of airborne chemical compounds.
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- Putting stem cell research on the fast track
09-12-2007 · EurekAlert!
Engineers at Rensselaer Polytechnic Institute have developed tools to help solve two of the main problems slowing the progress of stem cell research -- how to quickly test stem cell response to different drugs or genes, and how to create a large supply of healthy, viable stem cells to study from only a few available cells.
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- MIT: 'Micro' livers could aid drug screening
11-18-2007 · EurekAlert!
MIT researchers have devised a novel way to create tiny colonies of living human liver cells that model the full-sized organ. The work could allow better screening of new drugs that are potentially harmful to the liver and reduce the costs associated with their development.
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- Taxol bristle ball: a wrench in the works for cancer
09-12-2007 · EurekAlert!
Rice University chemists have discovered a way to load dozens of molecules of the anti-cancer drug Taxol onto tiny gold spheres. The result is a ball many times smaller than a living cell that literally bristles with the drug. Researchers hope to use the Taxol bristle ball to deliver large quantities of Taxol directly to cancer cells. The research will appear in the Sept. 19 issue of the Journal of the American Chemical Society.
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- 'Micro' livers could aid drug screening
11-19-2007 · Massachusetts Institute of Technology (MIT)
MIT researchers have devised a novel way to create tiny colonies of living human liver cells that model the full-sized organ. The work could reduce costs and allow better screening of new drugs that are potentially harmful to the liver.
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- CTRC enrolls first patients in Novel Phase II study for sarcoma -- Living virus destroys cancer cell
07-24-2007 · EurekAlert!
The Cancer Therapy & Research Center Institute for Drug Development, in collaboration with Oncolytics Biotech Inc., a biotechnology company, has enrolled the first two patients in a new Phase II clinical study for patients with various types of sarcomas that have metastasized to the lung. The novel anti-cancer therapy, REOLYSIN, is a living virus, not a chemotherapy drug, that is toxic to cancer cells but not harmful to normal cells.
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- Unstable leukemia stem cells may predispose patients to drug resistance
05-01-2007 · EurekAlert!
The BCR-ABL gene in chronic myeloid leukemia stem cells has a tendency to quickly mutate, and this may help explain why patients are predisposed to resistance to drugs like imatinib that target that gene, according to a study in the May 2 Journal of the National Cancer Institute.
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- Networking around the clock
04-05-2007 · EurekAlert!
A Brandeis University study published in Cell this week shows for the first time experimentally that the circadian cells in fruit flies function as a network that enables the insects to adapt their behavior according to seasonal changes. This discovery leads the way to understanding how mammals, and presumably humans, adjust physiology and behavior to environmental changes such as short winter days and long summer ones.
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