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2 heads are better than 1: 2 dysfunctional DNA repair pathways kill tumor cells
04-12-2007 · EurekAlert!Individuals who inherit one mutant copy of any one of about 12 genes that make the proteins of the Fanconi Anemia pathway are at increased risk of developing cancer. This occurs when the remaining "good" copy of the gene becomes mutated in a specific cell type. However, hope of a new treatment for these cancers has now been provided by a new study indicating that inhibiting the protein ATM can kill these cancer cells.
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Keywords: heads, dysfunctional, dna, repair, pathways, kill, tumor, cells, head, pathway, cell
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- JCI table of contents: April 12, 2007
04-12-2007 · EurekAlert!
This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, April 12, 2007, in the JCI, including: Two heads are better than one: two dysfunctional DNA repair pathways kill tumor cells; Alternative inhibition strategy for treating acute promyleocytic leukemia; Not all leaks are bad: plugging a calcium leak linked to familial Alzheimer disease; and others.
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- Sidestepping cancer's chaperone
10-18-2007 · EurekAlert!
Researchers at the University of Massachusetts Medical School, have defined a method to target and kill cancer's 'chaperone' -- a protein that promotes tumor cell stability and survival -- without damaging healthy cells nearby.
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- CSHL scientists identify cells that promote formation of lethal lung metastases
01-10-2008 · EurekAlert!
Cancer patients usually ask what can be done after a primary tumor has already spread, or metastasized, to other organs. In many cases, they learn, little can be done. Hence the importance of a discovery by scientists at Cold Spring Harbor Laboratory of a type of cell that regulates the transformation of small, dormant lung metastases into large, aggressive metastases -- the kind that kill cancer patients.
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- Signal protein shows promise for blocking tumor promoters in skin cells
11-03-2006 · EurekAlert!
A protein with the ironic name "Srcasm" can counteract the effects of tumor-promoting molecules in skin cells. Using animal models, the researchers discovered that Srcasm acts like a brake in epithelial cells, preventing uncontrolled cell growth caused by a family of proteins called Src kinases. This finding, published online in the Journal of Biological Chemistry, suggests a target for future gene therapy to treat skin, head, neck, colon and breast cancers.
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- Pathway links inflammation, angiogenesis and breast cancer
08-09-2007 · EurekAlert!
A well-known inflammatory protein spawns an enzyme that inactivates two tumor-suppressing genes, ultimately triggering production of new blood vessels to nourish breast cancer cells, researchers at the University of Texas M. D. Anderson Cancer Center report in the August edition of the journal Cell.
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- Enzyme alerts cell's powerful army to repair DNA damage
09-05-2007 · EurekAlert!
Each day cells detect and repair daily assaults to our DNA. University of Michigan researchers have discovered that a well-known enzyme scans genes for damage and alerts the major cancer suppressor protein p53. The finding has implications for treating cancer and neurological diseases.
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- Where broken DNA is repaired
08-02-2007 · EurekAlert!
Intricate DNA repair mechanisms in cell nuclei are constantly working to fix damaged DNA, but for mammalian cells, exactly where the repair work happens has been an unanswered question. By comparing computer models of damaged human DNA with microscopic images of radiation-induced damage in human cells, researchers at Lawrence Berkeley National Laboratory and their colleagues have found evidence for specific regions where broken DNA is concentrated for repair.
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- Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
08-30-2007 · EurekAlert!
A drug that shuts down a critical cell-signaling pathway in the most common and aggressive type of adult brain cancer successfully kills cancer stem cells thought to fuel tumor growth and help cancers evade drug and radiation therapy, a Johns Hopkins study shows.
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- Stem cell marker identified in head and neck cancer
01-16-2007 · EurekAlert!
Researchers have found a marker on head and neck tumor cells that indicates which cells are capable of fueling the cancer's growth. The finding is the first evidence of cancer stem cells in head and neck tumors.
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- Pathway to cell death redefined in landmark study
09-20-2007 · EurekAlert!
Researchers from the University of Pittsburgh School of Medicine have determined that an intracellular protein called serpin-6 is crucial to the repair and survival of cell injury. Controlling the process could pave the way to new treatments for cancer, stroke, heart disease, neurological disorders and other killer illnesses. Using a primitive animal model, the scientists also have made cascade of cell death and the role of serpin-6 in saving cells dramatically -- and explosively -- visible.
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