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Gene therapy, cancer-killing viruses and new drugs highlight novel approaches to cancer treatment
04-17-2007 · EurekAlert!Studies presented at the 2007 meeting of the American Association for Cancer Research show how researchers are using the new, as well as the natural, to help design and test new drugs to treat cancer.
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Keywords: gene, therapy, cancer-killing, viruses, drugs, highlight, novel, approaches, cancer, treatment, killing, viruse, drug, approache
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- Researchers find relief for chronic pain
01-21-2008 · EurekAlert!
Researchers in the Department of Medicine and Department of Neurosciences at Mount Sinai School of Medicine have discovered that chronic pain can be successfully treated with novel targeted gene therapy. In an effort to find a more effective treatment for chronic pain, researchers at Mount Sinai developed a gene therapy technique that simulates the pain-killing effect of opiate drugs.
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- Blocking cancer-causing gene improves radiation effectiveness, Jefferson researchers find
11-08-2006 · EurekAlert!
Inhibiting a particular cancer-causing gene can enhance the cell-killing effects of radiation, a team of radiation oncologists and cancer biologists has found. Using a combination of zebrafish and antisense technology, they've shown that the drug flavopiridol works by blocking the activity of a gene, cyclin D1, which is overexpressed in about half of all breast cancers. Similar techniques in the future, the scientists say, may enable researchers to better gauge the effects of drugs.
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- Discovery of widespread tumor growth gene holds promise for effective anti-cancer treatment
09-23-2007 · EurekAlert!
Italian scientists will announce on Monday (Sept. 24) that they have found a new and promising target for anti-tumor therapy in cancer. Professor Saverio Alberti, from the CESI, University of Chieti Foundation, Chieti, will tell the European Cancer Conference that he and his team have found a widespread mechanism for the stimulation of tumor growth in man, and that this is leading to the development of novel diagnostic and therapeutic procedures.
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- Gene profiling predicts resistance to breast cancer drug Herceptin
02-20-2007 · EurekAlert!
Using gene chips to profile tumors before treatment, researchers at Harvard and Yale Universities found markers that identified breast cancer subtypes resistant to Herceptin, the primary treatment for HER2-positive breast cancer. They say this advance could help further refine therapy for the 25 to 30 percent of breast cancer patients with this class of tumor.
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- Blood-vessel blocker aids cancer-killing virus
11-27-2007 · EurekAlert!
Cancer-killing viruses are a promising therapy for incurable brain tumors, but their effectiveness has been limited in part because immune cells rapidly eliminate them. That immune response might be slowed, and the virus given more time to kill cancer cells, by blocking the growth of blood vessels in the tumor, new Ohio State research suggests. The study indicates that pretreatment with a drug that blocks blood-vessel growth might improve the effectiveness of cancer-killing viruses.
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- Modeling lung cancer
02-12-2007 · EurekAlert!
In a new report in the February 15 issue of G&D, Dr. Martin McMahon and colleagues present a novel mouse model of non-small cell lung cancer, which will serve as a useful tool to test the efficacy of novel chemotherapeutic drug therapies in the early stages of lung tumorigenesis. Their paper provides evidence to support the use of a relatively new class of drugs, called MEK inhibitors, for lung cancer patients whose tumors contain mutations in the BRaf gene.
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- Cancer drug works by overactivating cancer gene
11-20-2007 · EurekAlert!
University of Michigan researchers have discovered that bortezomib, a promising cancer drug, is able to strike a blow against melanoma tumor cells by revving up the action of a cancer-promoting gene. The results suggest a novel treatment strategy: push cancer cells into overdrive, so that they self-destruct. The laboratory-based findings may lead to ways to give bortezomib with reduced side effects.
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- A new computational technique predicts side-effects of a major cancer drug
11-27-2007 · EurekAlert!
Researchers at the University of California San Diego have developed a novel computer technique to search for the side effects of major pharmaceuticals. The study, reported Nov. 30 in PLoS Computational Biology, relates to a class of drugs known as Select Estrogen Receptor Modulators, which includes tamoxifen, the most prescribed drug in the treatment of breast cancer.
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- Studies highlight advances in diagnosis, medical therapy
03-26-2007 · EurekAlert!
Three studies being presented today at the American College of Cardiology’s Innovation in Intervention: i2 Summit 2007 highlight the breadth of research propelling advances in clinical cardiology. One study explores the best medical and interventional treatment for patients with acute coronary syndromes, the second demonstrates the long-lasting promise of non-surgical approaches to the repair of heart valves, and the third highlights a new drug-exercise combination that improves image quality and reduces side effects.
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- Gene chip data improved therapy in some patients with incurable cancer
09-19-2007 · EurekAlert!
Like many oncologists, Eric P. Lester, M.D., was faced with a dilemma: seven patients with advanced, incurable cancer; an arsenal of drugs that may or may not help them; and not enough solid proof about treatment efficacy to guide him. So, Dr. Lester devised what he called a "simple-minded experiment" that illustrates the promise of personalized medicine.
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