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Jefferson researchers boost immune 'killer cells,' increase antibody effectiveness against cancer
04-18-2007 · EurekAlert!Researchers have devised a novel method to expand the number of immune system "natural killer (NK)" cells from blood cells outside the body. They have shown in laboratory studies that adding such cells to anti-cancer therapies involving monoclonal antibody drugs such as Herceptin, which targets the HER2/neu protein on breast cancer cells, is more effective in killing cancer cells, and perhaps someday may improve treatments.
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- A friendly foe -- Bacteria residing in the gut boost immune response to tumors
07-26-2007 · EurekAlert!
Total body irradiation (TBI), which depletes the body of lymphocytes, improves the ability of tumor-specific T cells to cause tumor regression. In a new JCI study researchers show that, in mice, lymphodepletion does not fully account for the tumor regression observed following TBI. They show that disruption of the population of bacteria that normally reside in the gut without causing disease also plays a role in the effectiveness of this therapeutic approach against cancer.
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- Jefferson scientists find aging gene also protects against prostate cancer development
11-27-2006 · EurekAlert!
Cancer researchers have found that a gene that is involved in regulating aging also blocks prostate cancer cell growth. They have shown that the enzyme SIRT1 can block the growth of treatment-resistant prostate cancer cells that overexpress a mutation for the androgen receptor. The scientists hope the newly found connection will aid in better understanding the development of prostate cancer and lead to new drugs against the disease.
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- Promising treatment target found in Hodgkin lymphoma
07-30-2007 · EurekAlert!
Dana-Farber Cancer Institute scientists have identified a protein that prevents the body's immune system from recognizing and attacking Hodgkin lymphoma cells. Based on this finding, the researchers are now investigating targeted therapies to disable this molecular "bodyguard" and boost a patient's ability to fight the blood cancer.
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- Brown researchers make major signal transduction discovery
10-04-2007 · EurekAlert!
How cells sense and respond to chemical messages -- a process known as signal transduction -- is a fundamental force in biology, controlling key processes such as cell growth and immune response. Now researchers from the Warren Alpert Medical School of Brown University and Rhode Island Hospital report a significant discovery in the field of signal transduction that could provide a new target for drugs that fight cancer, HIV and diseases. Results are published in Cell.
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- An AIDS-related virus reveals more ways to cause cancer, Penn researchers find
10-08-2007 · EurekAlert!
Researchers have shed new light on how Kaposi's Sarcoma-associated Herpes Virus subverts normal cell machinery to cause cancer. A KSHV protein called latency-associated nuclear antigen (LANA) helps the virus hide out from the immune system in infected cells. When LANA takes the place of other proteins that control cell growth, it can cause uncontrolled cell replication.
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- A faster way to recover from chemotherapy and marrow transplant
06-20-2007 · EurekAlert!
Researchers at Children's Hospital Boston report finding a practical way to increase stem cells in blood, suggesting a possible treatment to help patients recover from chemotherapy or bone marrow transplant for cancer, regaining immune function more quickly. The discovery, reported in the June 21 Nature and made possible through high-volume drug screening in fish, marks the first time stem-cell production has been induced by a small-molecule drug.
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- Jefferson scientists find protein helps pancreatic cancer cells evade immune system and spread
01-10-2008 · EurekAlert!
A protein that helps prevent a woman's body from rejecting a fetus may also play an important role in enabling pancreatic cancer cells to evade detection by the immune system, allowing them to spread in the body. Researchers found that the metastatic pancreatic cancer cells in the lymph nodes produce enough of the protein, IDO, to wall-off the immune system's T-cells and recruit cells that suppress the immune response to the tumor.
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- Immune cell communication key to hunting viruses, Jefferson immunologists show
10-25-2006 · EurekAlert!
Immunologists have used nanotechnology to create a novel "biosensor" to solve in part a perplexing problem in immunology: how the immune system's killer T-cells hunt down invading viruses. They have found that surprisingly little virus can turn on killer T-cells, thanks to some complicated communication among "antigen presenting" proteins that recognize and attach to the virus, making it visible to the immune system. Presenting proteins cooperate, spreading a signal among receptors and boosting T-cell response.
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- Antibody retards growth and induces death in liver cancer cells
07-11-2007 · EurekAlert!
Researchers from the University of Pittsburgh School of Medicine report a significant new advance in the search for an effective treatment for human liver cancer. Using a newly available monoclonal antibody, they demonstrated dramatic reductions in tumor cell proliferation and survival in human and mouse hepatocellular cancer cell lines. This finding has significant implications not only for the treatment of liver cancer but for a number of different types of cancer.
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- T vs. B: Re-engineered human T cells effectively target and kill cancerous B cells
09-18-2007 · EurekAlert!
Human white blood cells, engineered to recognize other malignant immune cells, could provide a novel therapy for patients with highly lethal B cell cancers such as acute lymphoblastic leukemia, according to researchers at Memorial Sloan-Kettering Cancer Center. By administering repeated doses of T cells designed to express an artificial receptor which recognizes human B cells, the researchers were able to eradicate cancer in 44 percent of mice bearing human ALL tumors.
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