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Why cisplatin kills breast cancer cells when other drugs fail
04-19-2007 · EurekAlert!The cancerous cells of some individuals with breast cancer lack expression of two cell surface proteins, the estrogen and progesterone receptors, and do not express increased amounts of HER2. Individuals with such breast cancer (known as triple-negative breast cancer) do not respond to treatment with commonly used chemotherapeutic drugs and their prognosis is relatively poor. But a new study has indicated why triple-negative breast cancer cell lines are sensitive to exposure to the chemotherapeutic cisplatin.
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Keywords: cisplatin, kills, breast, cancer, cells, drugs, fail, kill, cell, drug
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- JCI table of contents -- April 19, 2007
04-19-2007 · EurekAlert!
This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, April 19, 2007, in the JCI, including: Why cisplatin kills breast cancer cells when other drugs fail; Why don’t mothers’ bodies reject their fetus?; Understanding how glucocorticoids work to stop skin irritation; Filling in the blanks: MAPKs mediate heart function defects in Emery-Dreifuss muscular dystrophy; and others.
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