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Study links faulty DNA repair to Huntington's disease onset
04-22-2007 · EurekAlert!Huntington's disease, an inherited neurodegenerative disorder that affects roughly 30,000 Americans, is incurable and fatal. But a new discovery about how cells repair their DNA points to a possible way to stop or slow the onset of the disease. The research was funded by the National Institutes of Health.
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Keywords: study, links, faulty, dna, repair, huntington, disease, onset, link
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- Study suggests new treatments for Huntington's disease
01-09-2008 · EurekAlert!
Working with fruit flies, researchers have discovered a new mechanism by which the abnormal protein in Huntington's disease causes neurodegeneration. They have also manipulated the flies to successfully suppress that neurodegeneration, which they said suggests potential treatments to delay the onset and progression of the disease in humans.
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- Unknotting DNA clue to cancer syndrome
08-02-2007 · EurekAlert!
A new UC-Davis study that explains the actions of a gene mutation that causes early onset cancer provides a fundamental insight into the mechanism of DNA-break repair.
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- Mayo Clinic discovers DNA repair as key to Huntington's disease
04-22-2007 · EurekAlert!
Mayo Clinic researchers, along with collaborators from the National Institutes of Health (NIH) and University of Oslo, Norway, have discovered that a miscue of the body’s genetic repair system may cause Huntington's disease, a fatal condition that affects 30,000 Americans annually by destroying their nervous system. Until now, no one knew how Huntington’s begins, only that it is incurable. The findings appear in the online issue of the journal Nature.
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- JCI table of contents: April 12, 2007
04-12-2007 · EurekAlert!
This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, April 12, 2007, in the JCI, including: Two heads are better than one: two dysfunctional DNA repair pathways kill tumor cells; Alternative inhibition strategy for treating acute promyleocytic leukemia; Not all leaks are bad: plugging a calcium leak linked to familial Alzheimer disease; and others.
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08-13-2007 · EurekAlert!
New evidence indicates that the loss of two types of brain cells -- not just one as previously thought -- may trigger the onset of symptoms associated with Parkinson's disease. The evidence, based on mouse models, shows a link between the loss of both norepinephrine and dopamine neurons and the delayed onset of symptoms associated with Parkinson's disease. It was originally thought that the loss of only dopamine neurons triggered symptoms. Dopamine is a neurotransmitter critical for coordinating movement.
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09-04-2007 · EurekAlert!
Results of a new study indicate a strong link between the loss of the neuronal receptor LR11and onset of mild cognitive impairment (MCI), often a harbinger of Alzheimer's disease. The findings also show that levels of LR11 in the brain tissue reflect the severity of cognitive impairment and may predict which individuals will progress to Alzheimer's disease.
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04-10-2007 · EurekAlert!
Scientists have long known that individuals with a certain gene are at higher risk for developing Alzheimer's disease. Now a new study helps explain why this is so. The research, led by scientists at the Oklahoma Medical Research Foundation, has uncovered a molecular mechanism that links the susceptibility gene to the process of Alzheimer's disease onset. The findings appear in the Journal of Neuroscience and may lead to new pathways for development of Alzheimer's therapeutics.
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04-20-2007 · EurekAlert!
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- Subtle signs can help predict Huntington's disease early
05-14-2007 · EurekAlert!
Subtle signs can help doctors predict that a person will develop Huntington's disease in the next few years, according to a study published in the May 15, 2007, issue of Neurology, the scientific journal of the American Academy of Neurology. Huntington's disease is a genetic disorder that affects movement, thinking, and some aspects of personality. There is no treatment or cure for the disease.
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