Daily non-political popular news in brief.
New genes identified in childhood fever-related seizures
04-23-2007 · EurekAlert!Researchers have localized two new genes that are associated with fever-related seizures that occur in infancy and childhood, according to a study published in the April 24, 2007, issue of Neurology, the scientific journal of the American Academy of Neurology.
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Keywords: genes, identified, childhood, fever-related, seizures, gene, fever, related, seizure
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- AVN944 inhibits IMPDH & induces apoptosis-related biomarkers in patients with hematologic cancers
12-11-2006 · EurekAlert!
IMPDH is highly upregulated in most hematological cancers and solid tumors -- an essential role in cancer cell synthesis of DNA and RNA. Inhibition of IMPDH represents a new and important approach to treat cancer. In a Phase I trial of AVN944, AvalonRx identified a set of 34 genes. These gene markers correlate with the biochemical effects of AVN944 on protein function -- believed to result in tumor cell apoptosis at the right doses.
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- AVN944 inhibits IMPDH and induces apoptosis-related biomarkers in patients with hematologic cancers
12-11-2006 · EurekAlert!
IMPDH is highly upregulated in most hematological cancers and solid tumors -- an essential role in cancer cell synthesis of DNA and RNA. Inhibition of IMPDH represents a new and important approach to treat cancer. In a Phase I trial of AVN944, AvalonRx identified a set of 34 genes. These gene markers correlate with the biochemical effects of AVN944 on protein function -- believed to result in tumor cell apoptosis at the right doses.
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- Gene neighbors may have taken turns battling retroviruses
12-20-2007 · EurekAlert!
A cluster of antiviral genes in humans has likely battled retroviral invasions for millions of years. New research now finds that in addition to the previously identified TRIM5 gene that can defend against retroviruses like HIV, a related gene right next door, called TRIM22, may have participated in antiviral defense.
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- Isolation of a new gene family essential for early development
08-22-2007 · EurekAlert!
Researchers at BRIC, University of Copenhagen, have identified new gene family essential for embryonic development. The family controls the expression of genes crucial for stem cell differentiation, and the results may contribute significantly to the understanding of cancer development. The results are published in Nature, and it follows up on two other high-impact articles on related gene families published in Nature and Cell by the same researchers within the last year.
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- Genome study shines light on genetic link to height
09-02-2007 · EurekAlert!
Using a new "genome-scanning" method, a team of scientists has identified the first robust link between genes and stature in humans. A single letter change in a gene called HMGA2 enables people who carry it to gain as much as a centimeter in height. The work provides insights into how genes hardwire growth in humans and suggests that finding additional height-related genes may be feasible.
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- Gene profiling can single out the worst cases of multiple myeloma and guide therapy
09-18-2007 · EurekAlert!
Multiple myeloma patients vary widely in how they respond to treatment, but now researchers at the Myeloma Institute for Research and Therapy at the University of Arkansas for Medical Sciences have identified a small subset of genes whose activity could predict high-risk cases and potentially guide therapy in the future.
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- Newly identified mechanism for silencing genes points to possible anti-cancer strategies
05-16-2007 · EurekAlert!
Scientists are only beginning to appreciate the extraordinary degree of control exercised over every step of the gene-to-protein production process. Only about 10 percent of human genes, for example, are active in a given cell at a given time, with the remaining 90 percent silenced by a various mechanisms. In a just-published study in Nature, scientists report an important new gene-silencing mechanism that points to promising potential targets for anti-cancer interventions.
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- Gene expression patterns predict rapid decline in idiopathic pulmonary fibrosis patients
05-30-2007 · EurekAlert!
University of Pittsburgh researchers have identified a specific genetic profile in a group of idiopathic pulmonary fibrosis (IPF) patients that indicates a far more rapid progression to complete pulmonary failure and death without a lung transplant in comparison with other patients. In collaboration with pulmonary scientists in Mexico and California, Pittsburgh researchers found 437 differentially expressed genes. Most IPF patients live about five years following diagnosis with the chronic lung disease.
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- Einstein researchers use novel approach to uncover genetic components of aging
08-24-2007 · EurekAlert!
People who live to 100 or more are known to have just as many -- and sometimes even more -- harmful gene variants compared with younger people. Now, scientists at the Albert Einstein College of Medicine of Yeshiva University have discovered the secret behind this paradox: favorable "longevity" genes that protect very old people from the bad genes' harmful effects. The novel method used by the researchers could lead to new drugs to protect against age-related diseases.
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- Unique role for blood formation gene identified
09-12-2007 · EurekAlert!
All blood cell production in adults depends on the steady work of a vital gene that if lost results in early bone marrow failure, Dartmouth Medical School cancer geneticists have found. Their research reveals an unexpected role for the gene in sustaining the adult blood-forming system, and opens novel strategies for targeting the gene, which is often involved in a type of childhood leukemia.
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