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Gene analysis might explain ethnic differences in sensitivity to chemotherapy in lung cancer
04-23-2007 · EurekAlert!Analysis of three genetic mechanisms that cause nonsmall cell lung cancer might explain why East Asians respond better than other ethnic groups to a certain type of chemotherapy, a team led by UT Southwestern Medical Center researchers has found.
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Keywords: gene, analysis, explain, ethnic, differences, sensitivity, chemotherapy, lung, cancer, analysi, difference
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- Gene analysis might explain ethnic differences in sensitivity to chemotherapy in lung cancer
04-23-2007 · UT Southwestern Medical Center
Analysis of three genetic mechanisms that cause non-small cell lung cancer might explain why East Asians respond better than other ethnic groups to a certain type of chemotherapy, a team led by UT Southwestern Medical Center researchers has found.
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- Gene variations point to why lung cancer drugs work better in Japanese vs. US patients
06-02-2007 · EurekAlert!
Recent clinical trials revealed that Japanese lung cancer patients survived longer and had a higher rate of side effects than US patients taking the same two drugs, paclitaxel and carboplatin. Now a new study by the Southwest Oncology Group uncovers genetic differences that may explain why. The results, embargoed for release 8:30 a.m. ET Saturday, June 2, are being highlighted at the American Society of Clinical Oncology annual meeting.
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- Jefferson researchers show chemotherapy and radiation together extend lung cancer patients' lives
11-09-2007 · EurekAlert!
Chemotherapy given at the same time as radiation therapy can help patients with a certain type of lung cancer live nearly 50 percent longer than they might have otherwise if the same treatment was given differently, according to an international team’s analysis of several trial results.
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- Lung cancer-derived EGFR mutants exhibit intrinsic differences in inhibitor sensitivity
03-12-2007 · EurekAlert!
A new study sheds light on how some small-molecule tyrosine kinase inhibitors, including two that are currently being used clinically to treat cancer, interact with wild-type and mutated forms of the epidermal growth factor receptor (EGFR).
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- Mayo Clinic: Gene expression profiling not quite perfected in predicting lung cancer prognosis
11-17-2006 · EurekAlert!
While there have been significant advances in the use of gene expression profiling to assess a cancer prognosis, a Mayo Clinic review and analysis of existing lung cancer studies shows that this technology has not yet surpassed the accuracy of conventional methods used to assess survival in lung cancer patients.
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- Key To Lung Cancer Chemo Resistance Revealed
10-13-2006 · ScienceDaily
Scientists at Johns Hopkins have discovered how taking the brakes off a "detox" gene causes chemotherapy resistance in a common form of lung cancer.
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- Linchpin gene may be useful target for new breast cancer therapies
09-15-2007 · EurekAlert!
University of Iowa researchers have discovered a gene that plays a linchpin role in the ability of breast cancer cells to respond to estrogen. The finding may lead to improved therapies for hormone-responsive breast cancers, and may explain differences in the effectiveness of current treatments.
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- Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
08-13-2007 · EurekAlert!
Prognostic factors commonly used by clinicians to assess men with prostate cancer do not adequately predict survival outcomes in Asian men living in America, according to the first comprehensive ethnic analysis of Asian-American men with prostate cancer.
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- Genetic differences point to ethnic and racial disparities in colorectal cancer risk
11-28-2007 · EurekAlert!
Risk of developing colorectal cancer is known to differ across ethnic and racial groups, and now an analysis of 26 studies, involving over 25,000 participants shows that some of these disparities might be explained by distinct patterns of genetic inheritance. A team of researchers, led by investigators at the University of Pittsburgh, present their findings today in Atlanta at the AACR conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, being held Nov. 27-30.
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- Novel EGFR ectodomain mutations in glioblastoma
12-18-2006 · EurekAlert!
The Epidermal Growth Factor Receptor, a so-called kinase protein, is often abnormally active in cancer. A new class of anticancer drugs inhibiting the activated EGFR kinase have shown to be effective against such cancers, especially lung cancer. In a new study in PLoS Medicine, researchers have catalogued and characterized the mutations in the EGFR gene that occur in glioblastoma, a deadly type of brain tumor.
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