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Stretching DNA to the limit

A group of researchers at Duke University have developed a method to measure changes in the mechanical properties of DNA upon irradiation with UV light. This work might pave the way for using stretch-release force spectroscopy measurements in DNA diagnostics.

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Keywords: stretching, dna, limit

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   Cancer chemoprevention is an active measure to limit/retard the progression and pathogenesis of malignancy. Herbal preparations constitute an important component of indigenous/traditional medicines. A study led by Prof. Malay Chatterjee from Jadavpur University, India reported the potential chemopreventive efficacy of an Indian medicinal plant Acanthus ilicifolius in preventing liver DNA damage and in remodeling hepatocellular malignant lesions in an animal model, which may have an ultimate benefit to human beings in near future.
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   06-04-2007 · EurekAlert!
   Northeastern University professor Mark C. Williams and colleague Ioana Vladescu have discovered a novel method for studying the DNA binding of small molecules with unprecedented accuracy. Their paper, titled "Quantifying force-dependent and zero-force DNA intercalation by single-molecule stretching," has been published in the May 2007 issue of the prestigious Nature Methods.
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3. Back to the future: Mastodon extends the time limit on DNA sequencing
   07-23-2007 · EurekAlert!
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4. Unknotting DNA clue to cancer syndrome
   08-02-2007 · EurekAlert!
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8. Genetic ancestral testing cannot deliver on its promise, study warns
   10-18-2007 · EurekAlert!
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9. Abnormal glutamine repeats interfere with key transcription factor, leading to neurodegeneration
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10. Media highlights in the Dec. 15 issue of Biophysical Journal
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