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MicroRNAs can be tumor suppressors

University of Virginia researchers have discovered that microRNAs, a form of genetic material, can function as tumor suppressors in laboratory studies.

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Keywords: micrornas, tumor, suppressors, microrna, suppressor

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1. MicroRNAs as tumor suppressors
   04-15-2007 · EurekAlert!
   In an upcoming Genes & Development paper, Drs. Yong Sun Lee and Anindya Dutta (UVA) reveal that microRNAs can function as tumor suppressors in vitro.
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2. Multicenter study nets new lung tumor-suppressor gene
   08-05-2007 · EurekAlert!
   Collaborating scientists in Boston and North Carolina have found that a particular gene can block key steps of the lung cancer process in mice. The researchers report in the journal Nature that LKB1 is not only a "tumor-suppressor" gene for nonsmall cell lung cancer in mice, it also may be more powerful than other, better-known suppressors. The study will be published on the journal's Web site on Aug. 5.
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3. Molecules may help predict survival in liver cancer
   01-30-2008 · EurekAlert!
   Tiny molecules that help cells regulate which proteins they make might one day help doctors predict which liver-cancer patients are likely to live longer than others. Researchers compared levels of microRNA in tumor cells and adjacent nontumor cells from liver-cancer patients, most of whom also had hepatitis and cirrhosis. Patients with poor disease-free survival had low overall levels of 19 particular microRNAs compared with those showing better survival after 16 years of follow-up.
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4. Does neural cell adhesion molecule-180 predict survival in colorectal cancer?
   11-02-2007 · EurekAlert!
   As cancer is one of the most fatal diseases worldwide, tumor markers and prognostic criterions are of great interest to researchers. Tumor suppressors and cell adhesion molecules play crucial roles in tumor pathophysiology, acting as potential targets for treatment modalities. NCAM-180 is a structural molecule that mediates cell-cell adhesion, resulting in tissue stabilization. It has been proposed as a tumor suppressor in colon carcinoma. A research group in Turkey has investigated the prognostic value of NCAM-180 in colorectal cancer.
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5. MicroRNAs may be key to HIV's ability to hide, evade drugs, Jefferson scientists find
   09-30-2007 · EurekAlert!
   Tiny pieces of genetic material called microRNA could be key to HIV's ability to evade detection in the immune system. Researchers have shown that when an HIV-infected individual receives a powerful cocktail of antiviral agents called HAART, the virus uses miRNAs to help it hide and remain practically undetectable, temporarily shutting down its ability to replicate. Learning to manipulate miRNA's inhibitory effects might have implications for new strategies against the virus.
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6. Algae Provide New Clues To Cancer
   10-13-2006 · ScienceDaily
   A microscopic green alga helped scientists at the Salk Institute for Biological Studies identify a novel function for the retinoblastoma protein (RB), which is known for its role as a tumor suppressor in mammalian cells. By coupling cell size with cell division, RB ensures that cells stay within an optimal size range.
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7. Small molecule derived from Rb2/p130 could act as cancer therapeutic
   03-20-2007 · EurekAlert!
   A small molecule derived from the spacer domain of the tumor-suppressor gene Rb2/p130 has demonstrated the ability to inhibit tumor growth in vivo and could be developed into an anti-cancer therapeutic, according to researchers at Temple University's Sbarro Institute for Cancer Research and Molecular Medicine.
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8. New study reveals for first time how BRCA1 mutations cause breast cancer
   12-09-2007 · EurekAlert!
   An international team of researchers led by Columbia University Medical Center's Herbert Irving Comprehensive Cancer Center and Sweden's Lund University has, for the first time, revealed how mutations in the BRCA1 gene lead to breast cancer. Findings show that one way BRCA1 mutations cause cancer is by knocking out a powerful tumor suppressor gene known as PTEN.
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9. Micro molecules can identify pancreatic cancer
   01-10-2007 · EurekAlert!
   A pattern of micro molecules can distinguish pancreatic cancer from normal and benign pancreatic tissue, new research suggests. The study examined human pancreatic tumor tissue and compared it to nearby normal tissue and control tissue for levels of microRNA (miRNA). It identified about 100 different miRNAs that are present usually at very high levels in the tumor tissue.
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10. Massive microRNA scan uncovers leads to treating muscle degeneration
    10-17-2007 · EurekAlert!
    An increasing number of genes have been linked to muscular dystrophy and related disorders that cause muscle weakness and wasting, but it's still largely unknown how these genes cause disease, and, more importantly, how to translate the discoveries into treatments. A report in PNAS this week finds a wealth of new clues about how muscle function is regulated by analyzing microRNAs -- tiny bits of code that govern gene expression.
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