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Statins protect smokers from lung damage
10-23-2006 · EurekAlert!In a new study presented at CHEST 2006, the 72nd annual international scientific assembly of the American College of Chest Physicians, current and former smokers who used statins had lower lung function decline than those not using statins, regardless of whether patients continued or stopped smoking.
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Keywords: statins, protect, smokers, lung, damage, statin, smoker
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- Atrogin breaks down the side effects of statins
11-08-2007 · EurekAlert!
Statins are a popular class of drugs used to successfully combat high cholesterol. However, the rare, but serious, and poorly understood side effect of skeletal muscle breakdown prevents more prevalent use of these drugs. New research in mice has now indicated that atrogin-1 is a critical mediator of statin-induced muscle damage and that inhibiting atrogin-1 function might protect against this unwanted side effect of statins.
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- Gene variations directly link inflammation to an increased risk for lung cancer
07-03-2007 · EurekAlert!
Variations in two genes related to inflammation may be a major risk factor for developing lung cancer, according to a team of scientists from the National Cancer Institute and the University of Texas M. D. Anderson Cancer Center. The effect of these genes is especially strong among heavy smokers, suggesting that the inflammatory response is important in modulating the damage caused by tobacco smoke.
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- Scientists identify gene responsible for statin-induced muscle pain
11-27-2007 · EurekAlert!
Statins, the popular class of drugs used to lower cholesterol, are among the most commonly prescribed medications in developed countries. But for some patients, accompanying side effects of muscle weakness and pain become chronic problems and, in rare cases, can escalate to debilitating and even life-threatening damage. Now a study led by investigators at Beth Israel Deaconess Medical Center, helps explain the source of these problems.
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- Statins reduce loss of function, keeping old lungs young - even in smokers
10-12-2007 · EurekAlert!
Statins are known to be good for lowering cholesterol and maybe even fighting dementia, and now they have another reported benefit: they appear to slow decline in lung function in the elderly -- even in those who smoke. According to researchers in Boston, it may be statins' anti-inflammatory and antioxidant properties that help achieve this effect.
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- Exercise can reduce a smoker's lung cancer risk, but quitting smoking is still most important
12-11-2006 · EurekAlert!
In a study of more than 36,000 women, researchers observed that smokers can reduce their risk of developing lung cancer by being physically active. However, they strongly caution that any relative benefit is dwarfed by the benefits gained from quitting smoking.
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- JCI table of contents: Nov. 8, 2007
11-08-2007 · EurekAlert!
This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, Nov. 8, 2007, in the JCI, including: Atrogin breaks down the side effects of statins; Sex, sugar, and metabolic disease; New mouse strain teaches us about GPCRs; Too many red blood cells spoil the mouse; Two faces for TNF-alpha in antiviral and antitumor immunity; Making mice breathe easy: a role for IL-1 in lung damage; and others.
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- Antioxidant protects against lung damage in silicosis
10-16-2006 · EurekAlert!
Levels of heme oxygenase-1 (HO-1), an antioxidant that protects against reactive oxygen species (damaging oxygen molecules that cause direct tissue injury), become elevated in the lungs of chronic silicosis patients and could represent a new treatment approach for the disease.These results appear in the second issue for October 2006 of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.
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- Deep drilling for 'black smoker' clues
11-07-2007 · EurekAlert!
A project to learn more about extracting energy from hot rocks on land should give clues about "black smokers," hydrothermal vents that belch superheated water and minerals deep below the ocean.
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- JCI table of contents -- March 1, 2007
03-01-2007 · EurekAlert!
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published March 1, 2007, in the JCI, including: Cells in the lung clear the air to prevent lung damage; What makes good cholesterol so “good” for us?; Genetic mutations cause CoQ10 enzyme deficiency; Natural antibodies in newborns recognize a limited spectrum of proteins; and How aldosterone keeps salt in the body.
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- New HIV vaccine target could solve mutation problem
11-08-2007 · EurekAlert!
While HERV are present in every cell, HIV may disrupt the normal constraints on HERV activity as it alters the cell to produce more HIV. A vaccine could be created containing HERV antigens that would stimulate T-cells targeting cells expressing HERV. Although the vaccine would not produce T-cells capable of recognizing HIV itself, it would evoke immune responses that could still protect people from becoming infected or limit the extent of damage caused by HIV.
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