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Reversing cancer cells to normal cells

A Northwestern University scientist describes new research that used an innovative experimental approach to provide unique insights into how scientists can change human metastatic melanoma cells back to normal-like skin cells -- by exposing the tumor cells to the embryonic microenvironment of human embryonic stem cells, the zebra fish and the chick embryo.

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Keywords: reversing, cancer, cells, normal, cell

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1. New insight into factors that drive muscle-building stem cells
   01-08-2008 · EurekAlert!
   A report in the January issue of Cell Metabolism, a publication of Cell Press, provides new evidence explaining how stem cells known as satellite cells contribute to building muscles up in response to exercise. These findings could lead to treatments for reversing or improving the muscle loss that occurs in diseases such as cancer and AIDS as well as in the normal aging process
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2. Cancer cells enlist adult stem cells to promote metastasis
   10-31-2007 · Massachusetts Institute of Technology (MIT)
   MIT and Whitehead institute scientists have managed to facilitate metastasis, finding evidence that some breast cancer cells recruit normal adult stem cells from bone marrow and force them to secrete a protein that fosters cancer cell movement and invasion.
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3. Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
   07-31-2007 · EurekAlert!
   Working with human colorectal cancer cells, a University of Minnesota team, led by cancer biologists Zigang Dong and Ann Bode, has found the potential culprit among a network of enzymes that relay signals inside cells to regulate such functions as cell growth, cancer development and programmed cell death. The work suggests that drugs designed to disable the enzyme, known as TOPK, could have anticancer benefits. The study appears in the July issue of the journal Gastroenterology.
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4. New molecules discovered that block cancer cells from modifying cell DNA
   10-11-2007 · EurekAlert!
   Researchers have discovered new small molecules that may prevent prostate cancer cells from turning off normal genes in a process that transforms normal cells into cancer cells. This significant discovery in the field of epigenetics has immediate implications in the development of new diagnostic tests and cancer medications.
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5. Role of TRPM8 in the development of prostate cancer
   05-17-2007 · EurekAlert!
   In normal prostate epithelium, cells coexist in many stages of development-differentiation, and disrupted differentiation and proliferation are major causes of cancer. A new study shows that the endoplasmic reticulum protein TRPM8 (ER-TRPM8) present in human prostate epithelial luminal cancer cells retains it’s function as a calcium release channel, independent of the differentiation state of the cell, and may be an important factor in controlling the growth of prostate cancer cells.
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6. Forever young: Differentiation blocked in tumor stem cells
   01-07-2008 · EurekAlert!
   A new comparison of normal stem cells and cancer stem cells reveals that the cancer stem cells are abnormally trapped at an early stage of development. The research, published by Cell Press in the January issue of Cancer Cell, significantly advances the understanding of glioma pathophysiology and provides new directions for design of therapeutic strategies that are targeted to specific types of tumors.
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7. Loss of cell's 'antenna' linked to cancer's development
   06-28-2007 · EurekAlert!
   Most normal vertebrate cells have cilia, small hair-like structures that protrude like antennae into the surrounding environment to detect signals that control cell growth. In a new study published in the June 29 issue of Cell, Fox Chase Cancer Center researchers describe the strong link between ciliary signaling and cancer, and identify the rogue engineers responsible for dismantling the cell's antenna.
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8. Cancer stem cell marker also drives transcription in normal cells
   01-17-2008 · EurekAlert!
   New research links the recently discovered function of a multi-faceted transcriptional complex to control of gene expression in both normal cells and cancer stem cells...
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9. FOXO factor promotes survival of oxygen-deprived cancer cells
   12-27-2007 · EurekAlert!
   Scientists report that an evolutionarily conserved transcription factor may have both positive and negative effects on the growth of tumors, depending on whether or not the tumor cells have enough oxygen. The research, published by Cell Press in the Dec. 28 issue of Molecular Cell, provides critical new information about how normal cells and cancer cells survive under stress.
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10. Now playing -- Cell migration LIVE!
    06-08-2007 · EurekAlert!
    Johns Hopkins researchers have found a way to directly observe cell migration -- in real time and in living tissue. In a report in the June 5 issue of Developmental Cell, the scientists say their advance could lead to strategies for controlling both normal growth and the spread of cancer, processes that depend on the programmed, organized movement of cells across space
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