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Fat tissue-derived hormone leptin increases e-cadherin expression, obesity-breast cancer link noted
04-29-2007 · EurekAlert!Being obese increases the risk of breast cancer in post-menopausal women, shortens the time between return of the disease and lowers overall survival rates. Researchers now report evidence on how leptin, a hormone found in fat cells, significantly influences breast cancer development and progression in mice.
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Keywords: fat, tissue-derived, hormone, leptin, e-cadherin, expression, obesity-breast, cancer, link, noted, tissue, derived, cadherin, obesity, breast
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- Brain circuits that control hunger identified
10-29-2007 · EurekAlert!
Researchers at UCLA have determined the brain circuits involved in hunger that are influenced by a hormone called leptin. In previous clinical trials, supplementation of leptin, the signaling molecule produced by fat cells, produced moderate weight loss in some obese patients, purportedly by inhibiting hunger and promoting feelings of being full. Thus, this new work suggests possible new targets for treating obesity.
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- Other highlights from the March 21 JNCI
03-20-2007 · EurekAlert!
Also in the March 21 JNCI are a study on the link between fat intake and breast cancer risk, a plant compound that may decrease breast cancer risk, a critique of the use of progression-free survival in cancer clinical trials, and a mutation to a mismatch repair gene that is associated with colorectal cancer.
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- Breast cancer and hormone therapy -- A looking-glass mirror?
07-24-2007 · EurekAlert!
A new study raises the issue of a direct link between breast cancer incidence and use of postmenopausal hormone therapy (HT). Breast cancer incidence and mammography screening rates during 1980-2006 showed similar but not synchronous periodic fluctuations. The implication that HT use equates to the risk of breast cancer is therefore too simplistic and inappropriate.
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- Scientists find brown fat master switch
07-10-2007 · EurekAlert!
Researchers at Dana-Farber Cancer Institute have identified a long-sought "master switch" in mice for the production of brown fat, a type of adipose tissue that generates heat and counters obesity caused by overeating. The findings suggest that turning up the equivalent switch in people might be a new strategy for treating overweight and obesity.
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- Other highlights in the July 24 JNCI
07-24-2007 · EurekAlert!
Also in the July 24 JNCI are studies on the effects of hormone therapy and mammography use on breast cancer, the roles of sex hormones and breast density in developing breast cancer, and the link between broccoli and aggressive prostate cancer.
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- Dense breasts, hormone levels are 2 separate, independent risk factors for breast cancer
08-20-2007 · EurekAlert!
The density of a woman's breast tissue and her level of sex hormones are two strong and independent risk factors for breast cancer, according to a team of researchers from Harvard and Georgetown universities. The finding dispels the common belief that the risk associated with dense breasts merely reflects the same risk associated with high levels of circulating sex hormones, they say.
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- Fat stem cells being studied as option for breast reconstruction
10-26-2006 · EurekAlert!
Breast cancer survivors might one day avoid the prospect of invasive breast reconstruction surgery, opting instead for an approach that would involve using stem cells from their own fat, suggest researchers who are studying the potential these cells may have for regenerating new breast tissue. In animal models, they hope to prove that an injection of fat stem cells that are seeded onto microscopic scaffold structures will enable production of durable, replacement soft tissue.
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- Researchers chart the genetic mechanisms behind the genesis of fat cells
11-06-2007 · EurekAlert!
Obesity is a well known risk factor for prostate, breast and colon cancer, but recent studies have shown that a protein responsible for generating fat cells also plays an important role in cancer. Researchers at the Genome Institute of Singapore have conducted, for the first time, a genome-wide analysis of how the protein, called perixosome proliferator-activated receptor gamma, turns on various genes related to obesity.
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- New link between estrogen and breast cancer
08-24-2007 · EurekAlert!
The female sex hormone estrogen turns on a gene linked to breast cancer, according to new research by Brisbane scientists.
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- Growth hormone is not the anti-aging bullet for healthy adults
01-15-2007 · EurekAlert!
A review of published data on use of human growth hormone by healthy elderly people found that the synthetic hormone was associated with small changes in body composition but not in body weight or other clinically important outcomes. Further, people who took GH had increased rates of unhealthy side effects such as soft tissue swelling, joint pain, carpal tunnel syndrome, and, in men, abnormal breast development and were also somewhat more likely to develop diabetes.
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