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Peramivir protects mice from lethal H5N1 infection

05-01-2007 · EurekAlert!

The antiviral drug peramivir might offer humans significant protection during a pandemic of the avian influenza virus H5N1, according to results of mouse studies conducted by investigators at St. Jude Children's Research Hospital.

Keywords: peramivir, protects, mice, lethal, h5n1, infection, protect

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Human antibodies protect mice from avian flu
05-28-2007 · EurekAlert!
An international team of scientists, including researchers from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, report using antibodies derived from immune cells from recent human survivors of H5N1 avian influenza to successfully treat H5N1-infected mice as well as protect them from an otherwise lethal dose of the virus.
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Antibodies protect mice from developing respiratory tularemia
06-27-2007 · EurekAlert!
A research team led by Dennis W. Metzger, Ph.D., at the Albany Medical College in New York has now shown that treating laboratory mice with a serum containing tularemia-specific antibodies protects the mice against F. tularensis, not only if given before exposure to lethal doses of inhalational F. tularensis but also up to 48 hours after exposure. These findings suggest a possible alternative treatment approach to traditional antibiotics.
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Agent protects cells from lethal effects of radiation even if given after exposure
05-08-2007 · EurekAlert!
Researchers at Washington University School of Medicine in St. Louis report they have developed an agent that protects cells from the lethal effects of radiation, regardless of whether it is given before or after exposure. Using this agent in mice, the investigators found that the treatment helped shield rapidly dividing cells that are most vulnerable to radiation-induced death, providing proof in principle that it is possible to fend off radiation damage.
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Effective Preventive Drug Against Bird Flu Developed In The Mouse
10-13-2006 · ScienceDaily
Researchers have developed what could be used as an effective preventive drug against bird flu. In a study published today in the open access journal Respiratory Research, researchers have created antibodies against the avian flu virus H5N1 that work in mice both as a preventive drug, or prophylaxis, when administered before infection, and as a treatment for bird flu.
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Effective preventive drug against bird flu developed in the mouse
10-12-2006 · EurekAlert!
Researchers have developed what could be used as an effective preventive drug against bird flu. In a study published today in the open access journal Respiratory Research, researchers have created antibodies against the avian flu virus H5N1 that work in mice both as a preventive drug, or prophylaxis, when administered before infection, and as a treatment for bird flu.
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Experimental vaccine protects mice against deadly 1918 flu virus
10-17-2006 · EurekAlert!
Federal scientists have developed a vaccine that protects mice against the killer 1918 influenza virus. They also have created a technique for identifying antibodies that neutralize this virus, a tool that could help contain future pandemic flu strains. These findings are important, the researchers say, to understanding and preventing the recurrence of the H1N1 influenza virus that caused the 1918 pandemic and to protecting against virulent flu strains in the future, including the H5N1 avian flu virus.
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Tips from the Journals of the American Society for Microbiology
07-16-2007 · EurekAlert!
In this issue: Combined immunization methods may offer long-term protection against H. pylori infection, New ferret model may measure pandemic potential of H5N1 influenza viruses in humans, and Defense mechanism found in infected ticks may protect against harmful parasite.
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Jefferson immunology researchers halt lethal rabies infection in brain
09-04-2007 · EurekAlert!
Immunology researchers have shown how a type of bat rabies infection can be prevented in mice -- even after the virus reaches the brain, when it is most lethal. They found that by opening the central nervous system's (CNS) protective blood-brain barrier, powerful infection fighting substances can swarm in, essentially driving off the invading virus. A better understanding of the process, they say, may lead to improved treatment for late-stage rabies infections in humans.
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Aerosol launches immune response in lungs to wipe out lethal infections
12-03-2007 · EurekAlert!
An inhaled immune system stimulant protects mice against lethal pneumococcal pneumonia and other deadly bacterial, viral and fungal infections of the lungs, a research team led by scientists at the University of Texas M. D. Anderson Cancer Center reports at a major scientific meeting.
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Intravenous gene therapy protects normal tissue of mice during whole-body radiation
11-07-2006 · EurekAlert!
Gene therapy administered intravenously could be used as an agent to protect vital organs and tissues from the effects of ionizing radiation in the event of large-scale exposure from a radiological or nuclear bomb. In the University of Pittsburgh study, mice were used to test the protective effects of manganese superoxide dismutase plasmid liposome (MnSOD-PL) gene therapy on the bone marrow during whole-body irradiation.
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