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pHLIP, a novel technology to locate and treat tumors
05-01-2007 · EurekAlert!Research teams at Yale University and the University of Rhode Island have demonstrated a new way to target and potentially treat tumors using a short piece of protein that acts like a nanosyringe to deliver "tags" or therapy to cells, according to a report in the Proceedings of the National Academy of Sciences.
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Keywords: phlip, novel, technology, locate, treat, tumors, tumor
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- Newly identified biomarker detects and regulates spread of brain tumors
11-10-2006 · EurekAlert!
Researchers have identified a novel biomarker for brain tumors and have uncovered a potential role the marker may play when the tumor spreads or comes back after treatment. The biomarker, a protein known as "soluble attractin," is normally absent in the central nervous system and is undetectable in cerebral spinal fluid unless malignant astrocytomas are present in the CNS. This newfound ability to identify biomarkers for malignant astrocytomas means physicians will have a minimally invasive method to track the success of treatments.
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- Holographic images use shimmer to show cellular response to anticancer drug
03-06-2007 · EurekAlert!
The response of tumors to anticancer drugs has been observed in real-time 3-D images using technology developed at Purdue University. The new digital holographic imaging system uses a laser and the same microchip used in household digital cameras, to see inside tumor cells. The device also may have applications in drug development and medical imaging.
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- AVN944 inhibits IMPDH & induces apoptosis-related biomarkers in patients with hematologic cancers
12-11-2006 · EurekAlert!
IMPDH is highly upregulated in most hematological cancers and solid tumors -- an essential role in cancer cell synthesis of DNA and RNA. Inhibition of IMPDH represents a new and important approach to treat cancer. In a Phase I trial of AVN944, AvalonRx identified a set of 34 genes. These gene markers correlate with the biochemical effects of AVN944 on protein function -- believed to result in tumor cell apoptosis at the right doses.
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- New breakthrough treatment for spinal cancer patients at Mount Sinai
05-16-2007 · EurekAlert!
The Mount Sinai Medical Center is the only hospital in New York City using the Novalis Shaped Beam Surgery System on spinal cancer. Novalis is the most advanced Stereotactic Radiosurgery technology available to treat cancer tumors in the spine. Doctors at Mount Sinai are at the forefront of this medical breakthrough in neurosurgery and radiation oncology, using this technology to control deadly and complicated tumors from the spine for the first time ever.
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- Innovative movies show real-time immune-cell activity within tumors
11-20-2006 · EurekAlert!
Using advanced new microscopy techniques in concert with sophisticated transgenic technologies, scientists have for the first time created three-dimensional, time-lapse movies showing immune cells targeting cancer cells in live tumor tissues. Immune cells called T cells can be seen actively migrating though tissues, making direct contact with tumor cells, and killing them. Insights from this new view of the body's on-board defenses against cancer may open the way for improved immunotherapies to treat the disease.
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- AVN944 inhibits IMPDH and induces apoptosis-related biomarkers in patients with hematologic cancers
12-11-2006 · EurekAlert!
IMPDH is highly upregulated in most hematological cancers and solid tumors -- an essential role in cancer cell synthesis of DNA and RNA. Inhibition of IMPDH represents a new and important approach to treat cancer. In a Phase I trial of AVN944, AvalonRx identified a set of 34 genes. These gene markers correlate with the biochemical effects of AVN944 on protein function -- believed to result in tumor cell apoptosis at the right doses.
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- Common virus may help doctors treat deadly brain tumors
10-22-2007 · EurekAlert!
A common human virus may prove useful in attacking the deadliest form of brain tumors, according to a study by researchers at Duke's Preston Robert Tisch Brain Tumor Center. The researchers said the finding is an important step in developing a vaccine that can attack the tumors by enlisting the help of the body's immune system.
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- 'Trojan Horse' agent halts bone metastasis in mice
11-15-2006 · EurekAlert!
A novel vascular targeting agent completely prevented the development of bone tumors in 50 percent of the mice tested in a preclinical study, providing early evidence that it could treat, or thwart, growth of tumors in bone, a common destination for a number of cancers when they start to spread.
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- Combination therapy reduces tumor resistance to radiation
06-07-2007 · EurekAlert!
Radiation is used to treat a variety of tumors as it causes hypoxia and tumor cell death. Recently, radiation-induced hypoxia was shown to trigger tumor resistance to radiation via the activation of new blood vessel formation (angiogenesis). In a new JCI study, researchers show that a combination of radiation treatment and the use of angiogenesis inhibitors such as canstatin is able to overcome HIF-1-dependent tumor survival and increase tumor cell death in mice.
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- Penn researchers identify new combination therapy that promotes cancer cell death
07-16-2007 · EurekAlert!
To test the ability of combined therapy, researchers administered TRAIL, a tumor necrosis factor, and sorafenib, an inhibitor currently used to treat renal cancer, to mice with colon carcinomas. It reduced the size of tumors in mice with few side effects
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