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HCV patients survival after liver transplantation is not improving

For liver transplant recipients without hepatitis C, survival has improved over time. However, for recipients with HCV, survival has not improved.

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Keywords: hcv, patients, survival, liver, transplantation, patient

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1. Patients over age 60 do well after liver transplantation
   10-02-2007 · EurekAlert!
   Patients who undergo liver transplantation at age 60 or above have one-year and five-year survival rates similar to those of younger patients and they experience fewer episodes of rejection.
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2. 24-week course of interferon-alpha therapy prolongs survival in patients hepatitis C virus
   11-02-2007 · EurekAlert!
   A group at Hiroshima University Hospital performed a matched historical controlled study on whether a 24-week course of interferon-alpha therapy, after curative treatment for primary hepatocellular carcinoma associated with hepatitis C virus, could influence tumor recurrence, patient survival, and liver function. Patients with sustained virological responses had reduced recurrence, prolonged survival and a preserved liver function. The group also determined that viral eradication was the most important factor in such patients.
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3. Predicting survival after liver transplantation
   11-05-2007 · EurekAlert!
   Patients awaiting liver transplantation who also suffer from other medical problems may face poorer survival after transplantation.
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4. Outcomes for patients with hepatitis B who need liver transplants
   03-02-2007 · EurekAlert!
   Survival rates are similar among patients with hepatitis B who are listed for liver transplantation, whether or not they have hepatocellular carcinoma (HCC), according to a new study in the March 2007 issue of Liver Transplantation. An accompanying editorial suggests that these results affirm the current policy on the allocation of donor livers.
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5. Liver transplant offers survival benefits for patients of all sizes
   12-04-2007 · EurekAlert!
   Patients with high BMIs experience a significant survival benefit from liver transplantation and had similar rates of mortality after transplant compared to patients with normal BMI.
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6. Model for predicting survival in liver patients has many applications but could be refined further
   03-01-2007 · EurekAlert!
   A review of the studies on the Model for End-Stage Liver Disease (MELD) found that it is an accurate predictor of survival of patients with a variety of liver diseases, is particularly useful in allocating organs for liver transplants, and can also be used to help determine the course of treatment in certain cases. However, it is possible to improve the accuracy of the model and efforts at refining will continue.
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7. Gene patenting -- steep cost for health care and patients
   05-07-2007 · EurekAlert!
   The drug trastuzumab (Herceptin) is used to treat HER2-positive breast cancer (a type of breast cancer that overexpresses the HER2 gene and accounts for about 25 percent of all breast cancers). Trastuzumab therapy improves the chances of survival; however, it has deleterious side effects and is expensive. Thus, it is important to accurately determine the patient's HER2 status.
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8. Higher nitric oxide levels increase survival in ALI/ARDS trial
   02-01-2007 · EurekAlert!
   In a large-scale, multicenter trial of patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS), researchers showed that higher levels of nitric oxide (NO) in patient urine were strongly associated with improved survival, more ventilator-free days and decreased rates of organ failure.
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9. Racial differences seen in steatosis in patients with hepatitis C
   01-02-2007 · EurekAlert!
   Caucasian patients with chronic hepatitis C virus (HCV) are more likely to have hepatic steatosis, or fat in the liver, compared to African-American patients. However, steatosis is not associated with HCV treatment response.
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10. Risk factors for diabetes following liver transplant
    01-04-2007 · EurekAlert!
    A new study on risk factors of new-onset diabetes mellitus (NODM) following liver transplant found that a history of obesity, impaired fasting glucose and hepatitis C infection (HCV) paired with the use of a particular immunosuppressant are associated with an increased risk of NODM. Since all of these factors can be detected prior to undergoing a transplant, treatment should be tailored to the patient's risk.
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