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DNA-damage test could aid drug development
05-14-2007 · EurekAlert!Researchers from Massachusetts Institute of Technology and Whitehead Institute have developed a cell culture test for assessing a compound's genetic toxicity that may prove dramatically cheaper than existing animal tests. This assay would allow genetic toxicity to be examined far earlier in the drug development process, making it much more efficient.
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Keywords: dna-damage, test, aid, drug, development, dna, damage
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- Genetic marker linked to aggressive prostate cancer
05-20-2007 · EurekAlert!
Northwestern University researchers have discovered that a recently identified genetic marker for prostate cancer is linked to a highly aggressive form of the disease. These findings ultimately will aid the development of a simple blood test to predict who is susceptible to this aggressive cancer. Knowing which patients carry this genetic marker also will guide doctors in how they treat the cancer. The study showed a strong hereditary component to this aggressive cancer.
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- New study suggests Concord grape juice may provide protection against breast cancer
08-09-2007 · EurekAlert!
According to a new study, published in the current issue of the Journal of Medicinal Foods, natural compounds in Concord grape juice protected healthy human breast cells from DNA damage. Healthy human breast cells were exposed in a test tube to an environmental carcinogen, benzo(a)pyrene, that is able to initiate a chain of events leading to breast cancer. However, the introduction of Concord grape juice compounds blocked the connection of the carcinogen to the DNA of the healthy cells.
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- MIT: 'Micro' livers could aid drug screening
11-18-2007 · EurekAlert!
MIT researchers have devised a novel way to create tiny colonies of living human liver cells that model the full-sized organ. The work could allow better screening of new drugs that are potentially harmful to the liver and reduce the costs associated with their development.
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- Calming Factor: DNA vaccine for MS passes initial test
08-18-2007 · Science News Online
A DNA vaccine against multiple sclerosis passes a safety trial and shows signs of suppressing immune-directed nerve damage.
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- Study finds flaws in cancer clinical trials
02-01-2007 · EurekAlert!
Cancer research and drug development are yielding more sophisticated candidate therapies, but investigators' methods to test them haven't kept pace, according to researchers at Memorial Sloan-Kettering Cancer Center. That could explain why so many experimental drugs fail in the final large and costly phase of testing, they say.
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- Radioactive 'understudy' may aid medical imaging, drug development
01-09-2008 · EurekAlert!
Broadway stars have understudies. Now, an increasingly popular radioactive isotope has its own stand-in. Developed in part by researchers at the National Institute of Standards and Technology, the substance might ultimately improve medical imaging, speed up clinical trials of many drugs and facilitate efforts to develop more individualized medical treatment.
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- Gene found to play a suppressor role in skin cancer development
02-06-2008 · EurekAlert!
Researchers at the Burnham Institute for Medical Research have provided genetic evidence that Activating Transcription Factor 2 plays a suppressor role in skin cancer development. ATF2 is a protein that regulates gene transcription, the first step in the translation of genetic code, in response to extracellular stresses such as ultraviolet light and ionizing radiation. This function of ATF2 in stress and DNA damage response suggests it may also play a role in tumor formation.
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- 'Guardian of the genome' protein found to underlie skin tanning
03-08-2007 · EurekAlert!
A protein known as the "master watchman of the genome" for its ability to guard against cancer-causing DNA damage has been found to provide an entirely different level of cancer protection: By prompting the skin to tan in response to ultraviolet light from the sun, it deters the development of melanoma skin cancer, the fastest-increasing form of cancer in the world.
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- Mouse DNA to aid biomedical research
10-25-2006 · EurekAlert!
Researchers announced today that they have successfully resequenced the DNA of 15 mouse strains most commonly used in biomedical research. More than 8.3 million single nucleotide polymorphisms were discovered among the genomes of the 15 mouse strains and the data are now publicly available. These new data will help researchers better understand complex genetic traits, such as why some individuals are more susceptible to certain diseases, and will serve as a valuable resource in determining how environmental agents influence the development of disease.
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- ATR checkpoint-activating DNA structure
04-14-2007 · EurekAlert!
As published in the April 15th issue of Genes & Development, Dr. Karlene Cimprich and colleagues at Stanford University have determined the minimal DNA structure sufficient to activate the ATR-mediated DNA damage checkpoint.
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