Daily non-political popular news in brief.
Pioneering study looks at p53’s Role in tumor-stroma interactions
10-25-2006 · EurekAlert!Researchers have conducted the first comprehensive study of the role an important tumor suppressor gene plays in cancer development. P53 is known as a major tumor suppressor that is frequently mutated in human cancer. In this study, researchers used novel proteomic techniques to identify the proteins secreted by cells specifically in response to p53. The findings suggest a newfound role for wt-p53 in the control of the tumor's ability to communicate with the normal stromal cells surrounding it.
Read more »
Keywords: pioneering, study, looks, p53, role, tumor-stroma, interactions, look, tumor, stroma, interaction
« Previous | Next »
Similar news on "Pioneering study looks at p53’s Role in tumor-stroma interactions":
- Pioneering study looks at p53's role in tumor-stroma interactions
10-25-2006 · EurekAlert!
Researchers have conducted the first comprehensive study of the role an important tumor suppressor gene plays in cancer development. P53 is known as a major tumor suppressor that is frequently mutated in human cancer. In this study, researchers used novel proteomic techniques to identify the proteins secreted by cells specifically in response to p53. The findings suggest a newfound role for wt-p53 in the control of the tumor's ability to communicate with the normal stromal cells surrounding it.
Similar news · Read more »
- Interaction between lymph and liver cells may affect immune response
11-01-2006 · EurekAlert!
A new study on the ability of liver cells to interact with T cells (lymph cells that play a role in regulating the immune response) found that such interactions do occur and demonstrated the mechanism by which they may take place. The results may help explain the altered immune responses that occur with aging and other conditions and may be useful in developing therapies for viral hepatitis and autoimmune diseases.
Similar news · Read more »
- Altered expression of ultraconserved noncoding RNAs linked to human leukemias and carcinomas
09-10-2007 · EurekAlert!
A new study provides evidence that noncoding RNAs and interactions between noncoding genes play a much greater role in human cancer than was previously understood. The research, published by Cell Press in the September issue of the journal Cancer Cell, may be useful for identifying tumor-specific signatures associated with diagnosis, prognosis and treatment of cancer.
Similar news · Read more »
- Parasites a key to the decline of red colobus monkeys in forest fragments
10-24-2007 · EurekAlert!
Forest fragmentation threatens biodiversity, often causing declines or local extinctions in a majority of species while enhancing the prospects of a few. A new study from the University of Illinois shows that parasites can play a pivotal role in the decline of species in fragmented forests. This is the first study to look at how forest fragmentation increases the burden of infectious parasites on animals already stressed by disturbances to their habitat.
Similar news · Read more »
- Stress hormones may play new role in speeding up cancer growth
11-01-2006 · EurekAlert!
New research here suggests that hormones produced as during periods of stress may increase the growth rate of a particularly nasty kind of cancer. The study showed that an increase in norepinephrine, a stress hormone, can stimulate tumor cells to produce two compounds. These compounds can break down of the tissue around the tumor cells and allow the cells to more easily move into the bloodstream.
Similar news · Read more »
- Tumor-suppressor gene is critical for placenta development
01-09-2007 · EurekAlert!
An important cancer-related gene may play a critical role in the development of the placenta, the organ that controls nutrient and oxygen exchange between a mother and her fetus during pregnancy, and perhaps in miscarriages. Those conclusions come from a new study of the retinoblastoma (Rb) gene in mice. In humans, this gene, when mutated, raises the risk of a rare cancer of the eye called retinoblastoma.
Similar news · Read more »
- Therapeutic peptide frees the protein p73 to kill tumor cells
03-08-2007 · EurekAlert!
p53 suppresses tumor development by inducing tumor cell death. However, targeting p53 for the treatment of cancer is confounded by the fact that genetic mutations cause loss or inactivation of p53 in approximately 50 percent of human cancers. Now, a new study indicates that targeting the p53-related protein p73 in mice induces the regression of established tumors of human origin, leading to the suggestion that p73 might be a viable target for developing anticancer therapeutics.
Similar news · Read more »
- Study suggests test for p53 is needed to prescreen patients for blood cancer drugs
03-09-2007 · EurekAlert!
Researchers have determined a way to prescreen cancer patients to see if they are suitable candidates for proteasome inhibitors, a promising class of anti-cancer drugs. They propose to test for p53, a well-known tumor-suppressor protein that is broken down by cellular machinery called proteasomes.
Similar news · Read more »
- 'Junk' DNA now looks like powerful regulator, Stanford researcher finds
04-23-2007 · EurekAlert!
Large swaths of garbled human DNA once dismissed as junk appear to contain some valuable sections, according to a new study by researchers at the Stanford University School of Medicine and the University of California-Santa Cruz. The scientists propose that this redeemed DNA plays a role in controlling when genes turn on and off.
Similar news · Read more »
- A friendly foe -- Bacteria residing in the gut boost immune response to tumors
07-26-2007 · EurekAlert!
Total body irradiation (TBI), which depletes the body of lymphocytes, improves the ability of tumor-specific T cells to cause tumor regression. In a new JCI study researchers show that, in mice, lymphodepletion does not fully account for the tumor regression observed following TBI. They show that disruption of the population of bacteria that normally reside in the gut without causing disease also plays a role in the effectiveness of this therapeutic approach against cancer.
Similar news · Read more »
