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Pediatric cancer stem cell identified: understanding the origin of ERMS
05-16-2007 · EurekAlert!As published in the June 1 issue of Genes & Development, Dr. Leonard Zon (Children's Hospital Boston) and colleagues have identified the cancer stem cell for rhabdomyosarcoma, the most common soft-tissue sarcoma of childhood.
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Keywords: pediatric, cancer, stem, cell, identified, understanding, origin, erms, erm
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- JCI table of contents: Jan. 24, 2008
01-24-2008 · EurekAlert!
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published Jan. 24, 2008, in the JCI: TNF-alpha antagonist stops inflammation-induced colon cancer in its tracks; Building stronger bones, one stem cell at a time; Understanding a cause of Lou Gehrig’s disease; Genetic link to one form of a very common pediatric illness; and I can see clearly now Epo has come and gone.
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- Isolation of a new gene family essential for early development
08-22-2007 · EurekAlert!
Researchers at BRIC, University of Copenhagen, have identified new gene family essential for embryonic development. The family controls the expression of genes crucial for stem cell differentiation, and the results may contribute significantly to the understanding of cancer development. The results are published in Nature, and it follows up on two other high-impact articles on related gene families published in Nature and Cell by the same researchers within the last year.
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- Protein maintains cross talk between cells that control hair growth
02-14-2008 · EurekAlert!
Researchers at Rockefeller University have identified a signaling molecule that is critical for a type of skin cell, called dermal papilla, to ratchet up or clamp down the activity of genes that give them their molecular identity. Without these signals, these skin cells lose their hair-inducing properties -- findings that may provide a new understanding of how stem cells differentiate.
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- Run amok enzyme causes same problems in both humans and fruit flies
12-18-2006 · EurekAlert!
An enzyme found at elevated levels in several human cancers has been linked to abnormal tumor growth in fruit flies, a discovery that provides a new model for understanding the link between stem cell biology and cancer, according to researchers at the University of Oregon.
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- Cancer stem cell subpopulation drives metastasis of human pancreatic cancer
09-12-2007 · EurekAlert!
Scientists have identified a distinct subpopulation of cancer stem cells (CSCs) that is responsible for metastasis of a deadly human pancreatic cancer. The research, published by Cell Press in the Sept. issue of the journal Cell Stem Cell, provides insight into the role of CSCs in cancer initiation, progression and metastasis, and suggests new directions for development of more effective therapeutics.
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- OHSU Cancer Institute research discovery opens new window to understanding chronic myeloid leukemia
12-09-2007 · EurekAlert!
Oregon Health & Science University Cancer Institute researchers have opened a new window into the roots of chronic myeloid leukemia (CML). "We are looking under the surface of CML to understand better where the cancer is coming from. We have discovered abnormal cells in the early stem cell population in some CML patients, which don't belong to the CML clone. These are abnormal cells that are not part of the CML clone," said Thomas Bumm, M.D., OHSU Cancer Institute member.
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- New cell type identified in cancer development
03-13-2007 · EurekAlert!
A team of scientists, led by Dr. Jian-Xin Gao, a researcher in the department of pathology at Ohio State University Medical Center, has identified a new set of cells he calls precancerous stem cells (pCSCs).
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- Forever young: Differentiation blocked in tumor stem cells
01-07-2008 · EurekAlert!
A new comparison of normal stem cells and cancer stem cells reveals that the cancer stem cells are abnormally trapped at an early stage of development. The research, published by Cell Press in the January issue of Cancer Cell, significantly advances the understanding of glioma pathophysiology and provides new directions for design of therapeutic strategies that are targeted to specific types of tumors.
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- USC study in Nature Genetics supports a stem cell origin of cancer
01-08-2007 · EurekAlert!
Researchers at the University of Southern California found genes that are reversibly repressed in embryonic stem cells are over-represented among genes that are permanently silenced in cancers.
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- Malaria and Epstein-Barr virus linked to pediatric cancer in Africa
06-07-2007 · EurekAlert!
Arnaud Chene and colleagues have identified CIDRla as the first microbial protein able to spur a latently EBV-infected cell into active production. Their results suggest that P. falciparum-derived proteins can lead to a direct reactivation of EBV during acute malaria infection, increasing the risk of Burkitt lymphoma development for children living in malaria-endemic areas.
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