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Natural immune-control system may aid treatment of autoimmune disease and tissue rejection
05-17-2007 · EurekAlert!The immune system’s ability to police itself may offer a new method of arresting the cells responsible for autoimmune diseases such as multiple sclerosis and for the rejection of transplanted organs and tissues, report scientists at Dana-Farber Cancer Institute.
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Keywords: natural, immune-control, system, aid, treatment, autoimmune, disease, tissue, rejection, immune, control
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09-16-2007 · EurekAlert!
A self DNA-peptide complex triggers an immune response like that caused by a virus or other invading microbe. Researchers believe this response is both a likely key driver of autoimmune disease and an integral part of an early warning system that flags tissue damage to launch a protective inflammatory response to injury.
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- Cause of nerve fiber damage in multiple sclerosis identified
10-16-2006 · EurekAlert!
Researchers have identified how the body's own immune system contributes to the nerve fiber damage caused by multiple sclerosis, a finding that can potentially aid earlier diagnosis and improved treatment for this chronic disease.
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- 'Nondanger' signal lowers immune reactions
05-15-2007 · EurekAlert!
Rheumatology researchers have discovered that a well-known cell receptor sends a signal to dampen the immune system. While not having an immediate application to treating disease, the finding raises the possibility that by targeting that receptor, physicians could stimulate a "nondanger" signal to rein in overzealous human immune responses. Controlling those responses could potentially protect transplant patients from rejection episodes or could relieve symptoms of autoimmune diseases such as rheumatoid arthritis and lupus.
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- Researchers find new way to block destructive rush of immune cells
01-14-2008 · EurekAlert!
Researchers have found a way to selectively block the ability of white blood cells to "crawl" toward the sites of injury and infection when such mobility drives disease, according to a study published today in the Journal of Experimental Medicine. The results suggest a new treatment approach for autoimmune diseases like rheumatoid arthritis, lupus and multiple sclerosis, and for conditions made worse by misplaced inflammation, like atherosclerosis, stroke and transplant rejection, researchers said.
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- Preventing graft-versus-host disease disease after bone marrow transplant -- without toxicity
12-11-2006 · EurekAlert!
Most patients undergoing bone-marrow transplant must receive powerful chemotherapy drugs to suppress their immune system and prevent their bodies from rejecting the donated cells. New research shows that this chemotherapy increases the risk for graft-versus-host disease -- but also suggests that this risk can be reduced by replacing a natural antibiotic that's depleted when patients undergo chemotherapy. A multicenter study led by Children's Hospital Boston and the Dana-Farber Cancer Institute is about to test this idea.
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- Bursts of waves drive immune system 'soldiers' toward invaders
08-13-2007 · EurekAlert!
Scientists have discovered that torrents of microscopic waves propel white blood cells toward invading microbes. The discovery -- recorded on videotape -- holds the potential for better understanding and treatment of cancer and heart disease.
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- Melanoma drug revs immune cells but cancer cells ignore it
09-01-2007 · EurekAlert!
A new study shows that an important drug used in the treatment of malignant melanoma has little effect on the melanoma cells themselves. Instead, it activates immune-system cells to fight the disease. The drug, called interferon alpha, is used to clean up microscopic tumor cells that may remain in the body following surgery for the disease. It is the only drug approved for this purpose.
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- Molecule that destroys bone also protects it, new research shows
05-08-2007 · EurekAlert!
An immune system component that is a primary cause of bone destruction and inflammation in autoimmune diseases such as rheumatoid arthritis actually protects bone in the oral cavity from infectious pathogens that play a major role in periodontal disease in humans, research at the University at Buffalo has shown.
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- Insights into cell movement likely to aid immune study, cancer research
01-07-2008 · EurekAlert!
Scientists at Washington University School of Medicine in St. Louis have used yeast cells to better understand a collection of proteins associated with the formation of actin networks, which are essential to cell movement. The cell's ability to move is important to a broad range of biomedical concerns, including understanding how immune system cells pursue disease-causing invaders and how metastasizing cancer cells migrate from a tumor.
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- Scientists isolate chemical in curry that may help immune system clear plaques found in Alzheimer's
07-16-2007 · EurekAlert!
Researchers isolated bisdemethoxycurcumin, the active ingredient of curcuminoids -- a natural substance found in turmeric root -- that may help boost the immune system in clearing amyloid beta, a peptide that forms the plaques found in Alzheimer's disease.
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