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Role of TRPM8 in the development of prostate cancer

05-17-2007 · EurekAlert!

In normal prostate epithelium, cells coexist in many stages of development-differentiation, and disrupted differentiation and proliferation are major causes of cancer. A new study shows that the endoplasmic reticulum protein TRPM8 (ER-TRPM8) present in human prostate epithelial luminal cancer cells retains it’s function as a calcium release channel, independent of the differentiation state of the cell, and may be an important factor in controlling the growth of prostate cancer cells.

Keywords: role, trpm8, development, prostate, cancer

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JCI table of contents -- May 17, 2007
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