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Targeted nanoparticles incorporating siRNA offer promise for cancer treatment
05-20-2007 · EurekAlert!The use of targeted nanoparticles offers promising techniques for cancer treatment. Researchers in the laboratory of Mark E. Davis at the California Institute of Technology have been using small interfering RNA (siRNA), sometimes known as silencing RNA, to "silence" specific genes that are implicated in certain malignancies. The results of this research are being presented this week at the NSTI Nanotech 2007 Conference in Santa Clara, Calif.
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Keywords: targeted, nanoparticles, incorporating, sirna, offer, promise, cancer, treatment, nanoparticle
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- Combined molecular-targeted and hormonal therapies offer promise in treating ovarian cancer
05-08-2007 · EurekAlert!
A combination of molecular-targeted therapy and hormonal therapy may be the most promising area of research for those seeking an effective treatment for ovarian cancer, according to a new review in the International Journal of Gynecological Cancer.
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- Fantastic voyage: Drug delivery by a nanoparticle
02-13-2008 · Massachusetts Institute of Technology (MIT)
An image portrays targeted nanoparticles delivering high doses of chemotherapy to cancer cells. A team including MIT Institute Professor Robert Langer has demonstrated the precision required to engineer a nanoparticle that is effective in targeted drug delivery.
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- MIT: Remote-control nanoparticles deliver drugs directly into tumors
11-16-2007 · EurekAlert!
MIT scientists have devised remotely controlled nanoparticles that, when pulsed with an electromagnetic field, release drugs to attack tumors. The innovation, reported in the Nov. 15 online issue of Advanced Materials, could lead to the improved diagnosis and targeted treatment of cancer.
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- Enzyme eliminated by cancer cells holds promise for cancer treatment
07-18-2007 · EurekAlert!
An enzyme that cancer cells eliminate, apparently so they can keep proliferating, may hold clues to more targeted, effective cancer treatment, scientists say.
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- Nanoparticles deliver drugs directly into tumors
11-20-2007 · Massachusetts Institute of Technology (MIT)
MIT scientists have devised remotely controlled nanoparticles that, when pulsed with an electromagnetic field, release drugs to attack tumors. The innovation could lead to the improved diagnosis and targeted treatment of cancer.
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- Epigenetic drugs, promising for breast cancer treatment
12-20-2006 · EurekAlert!
Worldwide, cancer persists as one of the most important diseases that affect the human being. The knowledge on the molecular bases of cancer generated during the last decades has been successfully translated into small but significant gains in overall cancer survival rates due to better primary prevention measures, improved diagnostic methods and the development of more effective and specific therapies, collectively termed "molecular targeted therapies." In the context of these new forms of treatment, epigenetic or transcriptional cancer therapy is clearly promising.
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- Breast cancer treatment heats up
03-06-2007 · EurekAlert!
In the March Journal of Nuclear Medicine, researchers demonstrate that miniscule bioprobes could be produced and used with molecularly targeted therapeutic heat to kill malignant breast cancer cells -- without damaging nearby healthy tissue.
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- Nanoparticles hitchhike on red blood cells: a potential new method for drug delivery
06-27-2007 · EurekAlert!
Polymeric nanoparticles are excellent carriers for delivering drugs. However, they are quickly removed from the blood, sometimes in minutes, rendering them ineffective in delivering drugs. This study reports that nanoparticles can be forced to remain in circulation by attaching to red blood cells. Prolonged circulation of nanoparticles in the blood may potentially open new opportunities for the treatment of conditions such as cancer and heart disease.
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- MIT model could predict cells' response to drugs
07-30-2007 · EurekAlert!
MIT researchers have developed a model that could predict how cells will respond to targeted drug therapies. Models based on this approach could help doctors make better treatment choices and drug developers identify the ideal compound. In addition, the model could help test the effectiveness of drugs for a wide range of diseases, including cancer, arthirtis, and immune system disorders.
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- Phase II study shows HRPC patients with bone metastases see improved survival with ZD4054
09-25-2007 · EurekAlert!
New Phase II data presented today suggest that ZD4054, a novel compound in development for the treatment of men with hormone-resistant prostate cancer, could offer a promising improvement in overall survival in men with metastatic HRPC who were asymptomatic or mildly symptomatic for pain.1 Patients who received ZD4054 10mg once-daily experienced a 45 percent reduction in the risk of death compared to placebo.
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