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Repair of DNA by Brca2 gene prevents medulloblastoma
05-18-2007 · EurekAlert!Investigators at St. Jude Children's Research Hospital have gained some of the first major insights into how certain genes known to prevent cancer also guide the normal development of the nervous system before birth and during infancy by repairing DNA damage.
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Keywords: repair, dna, brca2, gene, prevents, medulloblastoma, prevent
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04-12-2007 · EurekAlert!
Individuals who inherit one mutant copy of any one of about 12 genes that make the proteins of the Fanconi Anemia pathway are at increased risk of developing cancer. This occurs when the remaining "good" copy of the gene becomes mutated in a specific cell type. However, hope of a new treatment for these cancers has now been provided by a new study indicating that inhibiting the protein ATM can kill these cancer cells.
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- Enhanced DNA-repair mechanism can cause breast cancer
10-15-2007 · EurekAlert!
Although defects in the "breast cancer gene," BRCA1, have long been known to increase the risk for breast cancer, exactly how the defects lead to tumor growth has remained a mystery. Now scientists provide insight into how the normal BRCA1 gene suppresses the growth of tumors as well as the nature of the genetic instability that leads to cancer when BRCA1 is defective.
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- The abortion pill compound prevents breast tumor growth
11-30-2006 · EurekAlert!
The chemical compound for the abortion pill has been found to prevent the growth of mammary tumors caused by the mutant gene responsible for a majority of breast and ovarian cancers, according to UC Irvine scientists.
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- Trainor Lab prevents rare birth defect by inactivating p53 gene
02-04-2008 · EurekAlert!
Using a mouse model of Treacher Collins syndrome, the Stowers Institute's Trainor Lab has demonstrated that it can prevent this rare disorder of craniofacial development either by inactivating a gene implicated in the abnormality or by inhibiting its protein product.
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- Bank on a Cure researchers identify pathways mediating myeloma treatment side effects
12-11-2006 · EurekAlert!
Thalidomide is a widely prescribed treatment for multiple myeloma. However, an estimated 15 to 30 percent of patients suffer venous thromboembolisms (VTEs), blood clots, as a major complication. The Bank On A Cure DNA-bank researchers have identified four gene clusters associated with the VTEs. Identifying the associated single nucleotide polymorphisms (SNPs) for use as markers, may lead to the development of screenings and tailored interventions to prevent these side effects, as a major step toward personalized medicine.
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- Possible new breast cancer gene
05-24-2007 · EurekAlert!
Researchers at the Abramson Family Cancer Research Institute of the University of Pennsylvania and the Dana-Farber Cancer Institute describe in this week’s issue of Science a new candidate breast-cancer susceptibility gene. The Rap80 gene is required for the normal DNA-repair function of the well-known breast cancer gene BRCA1.
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- Unknotting DNA clue to cancer syndrome
08-02-2007 · EurekAlert!
A new UC-Davis study that explains the actions of a gene mutation that causes early onset cancer provides a fundamental insight into the mechanism of DNA-break repair.
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- Nanoscale microscope sheds first light on gene repair
11-13-2006 · EurekAlert!
Proteins called H2AX act as "first aid" to DNA, among other roles. For the first time, scientists using the world's most powerful light microscope (the only one of its kind in the Americas) have seen how H2AX is distributed in the cell nucleus: in clusters, directing the first aid/repair after DNA injuries to the region where it is really needed.
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- UD researchers discover promising technique for repairing gene that causes spinal muscular atrophy
02-11-2008 · EurekAlert!
Researchers at the University of Delaware have discovered a novel technique -- that acts like a "spell-checker" for correcting a misspelling in the DNA code -- to repair the defective gene that causes spinal muscular atrophy. This hereditary neuromuscular disease is the number-one genetic killer of children under two years old.
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- UD researchers discover technique for repairing gene defect that causes spinal muscular atrophy
02-11-2008 · EurekAlert!
Researchers at the University of Delaware have discovered a novel technique -- that acts like a "spell-checker" for correcting a misspelling in the DNA code -- to repair the defective gene that causes spinal muscular atrophy. This hereditary neuromuscular disease is the number-one genetic killer of children under two years old.
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