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Scavenger cells may have role blocking obesity, Stanford study shows
05-21-2007 · EurekAlert!Macrophages - the scavenger cells of the body's immune system -- are known as troublemakers for the role they play in obesity, but Stanford University School of Medicine researchers have found that the cells can also be saviors when it comes to metabolism.
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Keywords: scavenger, cells, role, blocking, obesity, stanford, study, shows, cell, show
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- Novel small molecule therapy shows benefit for anemic patients via hydration of red blood cells
02-05-2008 · EurekAlert!
Researchers are identifying innovative therapeutics for sickle cell anemia that focus on specific factors in the disease's progression, such as the important role of hydration of the red blood cells. According to a study prepublished online in Blood, the official journal of the American Society of Hematology, a novel small molecule therapy called senicapoc showed efficacy in maintaining hydration of red blood cells and increasing hemoglobin levels in patients with sickle cell anemia.
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- Role of TRPM8 in the development of prostate cancer
05-17-2007 · EurekAlert!
In normal prostate epithelium, cells coexist in many stages of development-differentiation, and disrupted differentiation and proliferation are major causes of cancer. A new study shows that the endoplasmic reticulum protein TRPM8 (ER-TRPM8) present in human prostate epithelial luminal cancer cells retains it’s function as a calcium release channel, independent of the differentiation state of the cell, and may be an important factor in controlling the growth of prostate cancer cells.
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- 3 proteins may play important role in nerve-cell repair
04-11-2007 · EurekAlert!
Some mature brain cells can grow new extensions when the amount of three particular proteins on their surface increases, a new study shows. The research examined three related receptor proteins, called GPR3, GPR6 and GPR12, on nerve cells in the brains of rats.
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- New role for sugars: Research shows connections between sugar modifications in cells and cancer
04-05-2007 · EurekAlert!
In a ground-breaking study published in the top journal, Cell, Dr. James Dennis, senior investigator at the Samuel Lunenfeld Research Institute at Mount Sinai Hospital, has discovered a new role for sugars on proteins.
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- New Joslin research identifies sirtuin protein instrumental in fat production and metabolism
08-15-2007 · EurekAlert!
A new Joslin Diabetes Center-led study has identified a protein found in fat cells that may play a major role in how fat is produced and stored, offering a new target for treatments to prevent obesity and reduce the risk for type 2 diabetes. This latest research appears in the August 2007 issue of Cell Metabolism.
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- Scripps research scientists show protein accelerates breast cancer progression in animal models
06-20-2007 · EurekAlert!
Scientists at the Scripps Research Institute have shown for the first time that a cytokine called pleiotrophin stimulates the progression of breast cancer in both animal and cell culture models. The study, which tested three separate models to determine the role of inappropriate expression of pleiotrophin, found that it produced striking increases in aggressiveness of the breast cancer cells themselves.
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- Common virus may contribute to obesity in some people, new study shows
08-20-2007 · EurekAlert!
A common virus may cause obesity in some people, according to new evidence in a controlled laboratory study. Scientists showed that infection with human adenovirus-36, long recognized as a cause of respiratory and eye infections in humans, transforms adult stem cells obtained from fat tissue into fat cells. The study, which might lead to new treatments for obesity, will be reported in August at the American Chemical Society national meeting in Boston.
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- Penn study points to new direction for pancreas cell regeneration
04-03-2007 · EurekAlert!
Past studies in tissue culture have suggested that one type of pancreas cell could be coaxed to transform into insulin-producing islet cells. Now, researchers at the University of Pennsylvania School of Medicine have demonstrated that these pancreatic acinar cells do not become insulin-producing cells in an animal model. However, they did show that injured pancreatic cells readily regenerate back into healthy acinar cells, which has implications for treating cancer and inflammation of the pancreas.
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- International HIV/AIDS trial finds risks increase on episodic antiretroviral therapy
11-29-2006 · EurekAlert!
Results from one of the largest HIV/AIDS treatment trials ever conducted show that a specific strategy of interrupting antiretroviral therapy more than doubles the risk of AIDS or death from any cause. In the study, the investigators used two predetermined levels of CD4+ T cells, the primary immune cell targeted by HIV, to guide them in respectively suspending or restarting the study participants on antiretroviral therapy.
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- Regulatory T cells require WASp if they are to prevent self-destruction
01-11-2007 · EurekAlert!
In humans, mutation of the gene encoding a protein known as WASp leads to susceptibility to infections and systemic autoimmunity. Most studies have focused on understanding how WASp deficiency causes defects in T cell activation, but a new study shows that in mice and humans a population of T cells known as regulatory T cells, which prevent other immune cells attacking the body's and causing autoimmunity, are also impaired in the absence of WASp.
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