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Mice, men make livers differently
05-21-2007 · EurekAlert!Scientists often study mice as a model for human biology and disease, because their basic biological processes are assumed to be essentially the same as those of humans. But now, a team of MIT researchers has uncovered a surprising difference. In a study of gene regulation in mouse and human liver cells, they found that master regulatory proteins function in very different ways in mice and humans.
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- Mice and men make livers differently
05-21-2007 · Massachusetts Institute of Technology (MIT)
Scientists often study mice as a model for human biology and disease, because their basic biological processes are thought to be essentially the same as those of humans. But now, a team of MIT researchers has found a surprising difference.
Similar news · Read more »
- Protein power: Researchers trigger insulin production in diabetic mice
01-08-2008 · EurekAlert!
University of Florida researchers have coaxed liver and pancreatic cells within diabetic mice into churning out insulin by injecting the animals with a naturally occurring protein called Pdx1, opening up a new research avenue that someday could lead to safer treatments for type 1 diabetes. Pdx1 activates the genes controlling the development of the pancreas cells that make and release insulin to maintain safe levels of glucose in the body.
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- Liver regeneration may be simpler than previously thought
04-11-2007 · EurekAlert!
The way the liver renews itself may be simpler than what scientists had been assuming. A new study, appearing in the April 13 issue of the Journal of Biological Chemistry, provides new information on the inner workings of cells from regenerating livers that could significantly affect the way physicians make livers regrow in patients with liver diseases such as cirrhosis, hepatitis or cancer.
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- Male contraception: One door opens, another closes
11-07-2006 · EurekAlert!
Researchers have announced a breakthrough on a non-hormonal compound known as Adjudin. When injected as an attachment to a modified hormone that seeks out the testes, a low dose is a safe and effective contraceptive in rats. However, another promising drug, miglustat, has failed to make the leap from mice to men.
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- Testosterone therapy may prevent Alzheimer's disease
12-19-2006 · EurekAlert!
Researchers at the University of Southern California have discovered a direct link between loss of testosterone and the development of an Alzheimer's-like disease in mice. They also discovered that testosterone treatment slows progression of the disease.The study, published in the Dec. 20 issue of the Journal of Neuroscience, predicts that testosterone-based hormone therapy may be useful in the treatment and prevention of Alzheimer’s disease in aging men.
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- Central and peripheral signals set the circadian liver clock
01-29-2007 · EurekAlert!
Research on mice engineered with an inducible liver clock enabled identification of some genes with expression controlled by the local clock, and other genes (including mPer2) that maintained circadian oscillations thanks to cues from the SCN.
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- Mayo Clinic Proceedings contributors discuss impact of donor organ allocation system
02-06-2008 · EurekAlert!
Liver transplant is a life saving treatment option for people with end-stage liver disease. Unfortunately, the need for donor livers far exceeds the supply. Each year only about one-third of people who need a donor liver will receive one, and some patients die while waiting. In the February issue of Mayo Clinic Proceedings, physicians explore how the current system for allocating donor organs in the United States affects outcomes for patients with end-stage liver disease.
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- Decreased TGF-beta signaling might make you demented
11-01-2006 · EurekAlert!
The physical changes that occur in the brain of patients with Alzheimer's disease, the most common cause of dementia in the elderly, have been well-characterized, but the cause(s) of this disease and the development of therapies has remained elusive. A new study now shows that decreased signaling through a receptor known as T-beta-RII -- expression of which is decreased in the neurons of patients with AD -- increases neurodegeneration in mice.
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- What's the difference between mice and men?
11-13-2006 · EurekAlert!
Evolutionary change in function of the dorsocentral enhancer (DCE) of scute has resulted in altered bristle formation between two species of Drosophila.
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- Researchers find gene mutation that causes infertility in male mice
04-10-2007 · EurekAlert!
Cornell University researchers have identified a mutation in a gene that causes male infertility in mice. Because this is the first time that a dominant mutation that leads specifically to infertility in a mammal has been discovered, the researchers say they can now look for similar mutations in the DNA of infertile men.
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