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Chemotherapy drug shrinks brain tumors
05-21-2007 · EurekAlert!Cancerous brain tumors appear to respond favorably to the drug temozolomide when used as primary chemotherapy after surgery, and the treatment appears to work best in people missing a certain gene, according to a study published in the May 22, 2007, issue of Neurology, the scientific journal of the American Academy of Neurology.
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Keywords: chemotherapy, drug, shrinks, brain, tumors, shrink, tumor
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- Genetically modified cells attack tumors
12-21-2006 · EurekAlert!
Mice with neuroblastoma tumors have been successfully treated with genetically modified cells that sought out the cancer cells and activated a chemotherapy drug directly at those sites, according to investigators at St. Jude Children's Research Hospital and their colleagues at City of Hope National Medical Center (Duarte, Calif.) and the University of British Columbia (Vancouver, Canada). Neuroblastoma is a solid tumor that arises in the part of the nervous system outside the brain.
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- Drug combination shrinks breast cancer metastases in brain
12-16-2007 · EurekAlert!
A combination of a "targeted" therapy and chemotherapy shrank metastatic brain tumors by at least 50 percent in one-fifth of patients with aggressive HER2-positive breast cancer, according to data presented by Dana-Farber Cancer Institute investigators at the San Antonio Breast Cancer Symposium.
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- Reactivated gene shrinks tumors
01-24-2007 · EurekAlert!
Many cancers arise due to defects in genes that normally suppress tumor growth. Now, for the first time, MIT researchers have shown that re-activating one of those genes in mice can cause tumors to shrink or disappear.
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- Blood-vessel blocker aids cancer-killing virus
11-27-2007 · EurekAlert!
Cancer-killing viruses are a promising therapy for incurable brain tumors, but their effectiveness has been limited in part because immune cells rapidly eliminate them. That immune response might be slowed, and the virus given more time to kill cancer cells, by blocking the growth of blood vessels in the tumor, new Ohio State research suggests. The study indicates that pretreatment with a drug that blocks blood-vessel growth might improve the effectiveness of cancer-killing viruses.
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- Reactivated gene shrinks tumors, MIT study finds
01-24-2007 · Massachusetts Institute of Technology (MIT)
Many cancers arise due to defects in genes that normally suppress tumor growth. Now, for the first time, MIT researchers have shown that re-activating one of those genes in mice can cause tumors to shrink or disappear.
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- Transplant drug sirolimus shrinks tumors, improves lung function
01-09-2008 · EurekAlert!
The drug sirolimus, normally used to help transplant patients fight organ rejection, may eventually be used as a less invasive treatment for a tumor called angiomyolipomata in patients with tuberous sclerosis complex or lymphangioleiomyomatosis who would otherwise face surgery. The finding is reported by investigators from Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine in the Jan. 10 edition of the New England Journal of Medicine.
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- Drug combination might offer hope for patients deadly brain tumors
10-18-2007 · EurekAlert!
Brain cancer patients with the poorest prognosis -- those with a type of deadly tumor known as glioblastoma multiforme -- may survive longer with a drug that chokes off a tumor's blood supply.
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- Drug helps brain tumor patients live longer
01-28-2008 · EurekAlert!
People who receive high doses of the chemotherapy drug methotrexate to treat a certain type of brain tumor appear to live longer than people receiving other treatments, according to research published in the Jan. 29, 2008, issue of Neurology, the medical journal of the American Academy of Neurology.
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- Researchers identify genes that allow brain cancer-causing stem cells to resist treatment
12-14-2006 · EurekAlert!
Researchers at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute, who first isolated cancer stem cells in adult brain tumors in 2004, have now found these cells to be highly resistant to chemotherapy and other treatments. Even if a tumor is almost completely obliterated, it will regenerate from the surviving cancer stem cells and be even more resistant to treatment than before.
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- 'Re-plumbing' liver helps beat cancer
09-26-2007 · EurekAlert!
A procedure that temporarily diverts blood leaving the liver during chemotherapy could prolong the lives of people with primary or secondary tumors. The blood supply leaving the liver is blocked using balloons, meaning the concentration of the chemotherapy drug working on the tumor is hundreds of times greater than normal -- increasing the chances of tumors being killed. Blood does still leave the liver via the balloons, but instead of carrying on to the heart as usual it is diverted out of the body.
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