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Anti-inflammatory drugs interact with HRT, and more
05-21-2007 · EurekAlert!Any cardio protective effect of hormone replacement therapy may be inhibited if women are taking a particular type of non-steroidal anti-inflammatory pain killer, report researchers led by Garret FitzGerald from University of Pennsylvania in a paper published this week in PLoS Medicine.
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Keywords: anti-inflammatory, drugs, interact, hrt, anti, inflammatory, drug
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- Study found no drug interference with pomegranate juice
08-20-2007 · EurekAlert!
A study published in the Journal of Clinical Pharmacology finds that pomegranate juice does not interact with medication. Earlier studies suggested that, like grapefruit juice, pomegranate juice may interfere with metabolism of drugs by inhibiting CYP3A, an enzyme that allows the body to transform and eliminate a drug. This is the first study using human subjects to test the drug interactions of pomegranate juice, unlike prior studies which were conducted in vitro and in animals.
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- Regular, long-term aspirin use reduces risk of colorectal cancer
01-22-2008 · EurekAlert!
The use of regular, long-term aspirin and non-steroidal anti-inflammatory drugs reduces the risk associated with colorectal cancer, according to a study published in Gastroenterology, the official journal of the American Gastroenterological Association Institute. However, the use of aspirin for chemoprevention of colorectal cancer may require using the drug at doses that are higher than recommended over a long period of time, which may cause serious side effects including gastrointestinal bleeding.
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- UCLA study identifies 'designer estrogen' as potential MS drug
08-27-2007 · EurekAlert!
While people with multiple sclerosis have many choices for anti-inflammatory drugs to help prevent flare-ups of their physical symptoms, no medication exists to stop MS from causing degeneration of the brain and spinal cord. Now a UCLA study finds that a new form of estrogen protects the brain without increasing the risk of hormone-induced cancers of the breast and uterus.
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- New Argonne study may shed light on protein-drug interactions
01-15-2008 · EurekAlert!
Proteins, the biological molecules involved in virtually every action of every organism, may themselves move in surprising ways, according to a recent study from the US Department of Energy's Argonne National Laboratory that may shed new light on how proteins interact with drugs and other small molecules.
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- MIT: 'Micro' livers could aid drug screening
11-18-2007 · EurekAlert!
MIT researchers have devised a novel way to create tiny colonies of living human liver cells that model the full-sized organ. The work could allow better screening of new drugs that are potentially harmful to the liver and reduce the costs associated with their development.
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- A vitamin B12 derivative could potentially be used to treat hypertension and heart disease
11-23-2007 · EurekAlert!
Nitric oxide is a very important regulator of blood pressure and blood flow to the heart and other organs. Several drugs such as nitroglycerin and sodium nitroprusside act by providing NO, but each of these drugs have drawbacks. Investigators at the University of California, San Diego have developed a drug that releases NO directly, which is unlikely to be toxic because it is a vitamin B12 derivative.
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- Catalyst Pharmaceutical Partners Announces Positive Phase II Trial Results for Vigabatrin in the Treatment of Cocaine Addiction
12-07-2007 · Brookhaven National Laboratory
Catalyst Pharmaceutical Partners, Inc. (Nasdaq: CPRX), a biopharmaceutical company that acquires, in-licenses, develops and commercializes prescription drugs for the treatment of drug addiction, today announced positive initial top-line results from an investigator-initiated Phase II double-blind, placebo-controlled trial, which demonstrates that vigabatrin is effective for the treatment of cocaine addiction. Catalyst's lead compound, CPP-109, is bioequivalent to vigabatrin.
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- Infliximab scheduled treatment has proven to be an effective strategy in IBD patients
10-25-2007 · EurekAlert!
Although many drugs have been used in the treatment of inflammatory bowel disease, none have yet been shown to modify the natural history of the diseases or to maintain a stable remission over time. The introduction of biological agents in the therapeutic armamentarium for Crohn's disease and ulcerative colitis has significantly changed the treatment strategies and outcomes of patients. Infliximab scheduled treatment has proven to be an effective strategy in IBD patients for long-term maintenance of clinical remission.
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- Gene Signatures Match Cancer And Other Diseases With Potentially Effective Drugs
09-29-2006 · ScienceDaily
In one of the most ambitious spinoffs of the human genome project, researchers at Dana-Farber Cancer Institute, Children's Hospital Boston, the Broad Institute of Harvard and MIT, and other collaborating centers have unveiled a new, systematic approach to drug discovery that matches diseases with potential treatments using a universal language based on cells' distinctive gene activity profiles, or "signatures."
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- Mouse Tests Predict Drug Response In Relapsing Pancreatic Cancer Patients
10-12-2006 · ScienceDaily
By slicing up bits of patient tumors and grafting them into mice, Johns Hopkins Kimmel Cancer Center specialists have figured out how to accurately 'test drive' chemotherapy drugs to learn in advance which drug treatments offer each individual pancreatic cancer patient the best therapeutic journey.
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