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Key gene controlling eye lens development identified
10-26-2006 · EurekAlert!Investigators at St. Jude Children's Research Hospital have discovered in mouse models that a gene called Six3 is one of the earliest critical regulators controlling lens development in the eye of the mammalian embryo.
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- Key Gene Controlling Kidney Development Found
10-14-2006 · ScienceDaily
A gene called Six2 plays a critical role in the development of the kidney by keeping a population of "parent" stem cells constantly available to produce the differentiated cells that give rise to specialized parts of the organ, according to investigators at St. Jude Children's Research Hospital.
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- Study reveals a key to blood vessel growth and possible drug target
10-14-2007 · EurekAlert!
Researchers have identified a molecular pathway that plays a critical role in the growth of blood vessels. The finding not only offers an important insight into the development of the vascular system during embryonic development but suggests a potential target for inhibiting the blood vessels that fuel cancers, diabetic eye complications and atherosclerosis, the researchers say.
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- Gene Key To Taste Bud Development Identified
10-02-2006 · ScienceDaily
Scientists have identified a gene that controls the development of taste buds. The gene, SOX2, stimulates stem cells on the surface of the embryonic tongue and in the back of the mouth to transform into taste buds, according to the researchers. Stem cells are immature cells that can develop into several different cell types depending on what biochemical instructions they receive.
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- Oregon researchers find trigger gene for muscle development
01-31-2008 · EurekAlert!
University of Oregon scientists say they have identified a gene that is the key switch that allows embryonic cells to form into muscles in zebrafish.
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- Role identified for glaucoma gene and related signaling pathway
02-14-2008 · EurekAlert!
Researchers have found that a gene and a related signaling pathway play a role in the development of glaucoma, which is a common cause of visual impairment and blindness worldwide. The study, which revealed that over-expression of the gene, sFRP1, elevates pressure in the eye, could help improve glaucoma diagnosis and lead to the development of sight-saving treatments.
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- Genetics a key factor in premature infants' devastating eye disease
11-22-2006 · EurekAlert!
Genetics play a major role in predisposing infants to retinopathy of prematurity (ROP), a disease prevalent in premature infants that disrupts normal blood vessel development of the retina and can lead to blindness, researchers at Yale School of Medicine report in the November issue of Pediatrics.
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- Scientists identify key to integrating transplanted nerve cells into injured tissue
04-26-2007 · EurekAlert!
Scientists at the Schepens Eye Research Institute, an affiliate of Harvard Medical School, have identified a key mechanism for successfully transplanting tissue into the adult central nervous system. The study found that a molecule known as MMP-2 (which is induced by stem cells) has the ability to break down barriers on the outer surface of a damaged retina and allow healthy donor cells to integrate and wire themselves into remaining recipient tissue.
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- 'Lucky 13' as new gene discovery offers further hope for childhood blindness
06-11-2007 · EurekAlert!
An international research team has discovered a gene that, when mutated, causes one of the most common forms of inherited blindness in babies. Scientists at the University of Leeds, working in collaboration with experts from other centres around the world, identified the gene, which is essential to photoreceptors in the eye, the cells that "see" light.
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- Bank on a Cure researchers identify pathways mediating myeloma treatment side effects
12-11-2006 · EurekAlert!
Thalidomide is a widely prescribed treatment for multiple myeloma. However, an estimated 15 to 30 percent of patients suffer venous thromboembolisms (VTEs), blood clots, as a major complication. The Bank On A Cure DNA-bank researchers have identified four gene clusters associated with the VTEs. Identifying the associated single nucleotide polymorphisms (SNPs) for use as markers, may lead to the development of screenings and tailored interventions to prevent these side effects, as a major step toward personalized medicine.
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- Sugar identified as key to malaria parasite invasion
09-10-2007 · EurekAlert!
Researchers at the Johns Hopkins Malaria Research Institute have identified a sugar in mosquitoes that allows the malaria-causing parasite to attach itself to the mosquito's gut. Invasion of the midgut cell layer is an essential stage in the parasite's lifecycle and in malaria transmission. By reducing the level of the sugar, chondroitin sulfate, in the mosquito, the researchers prevented 95 percent of the parasites in the mosquito from attaching to the gut, thus blocking its development.
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