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New mouse model closely mimics human cancers
05-24-2007 · EurekAlert!A team led by Dana-Farber Cancer Institute scientists has developed a more human-like mouse model of cancer they say will aid the search for cancer-causing genes and improve the predictive value of laboratory drug testing.
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Keywords: mouse, model, closely, mimics, human, cancers, mimic, cancer
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- It's a knock out: eIF4E-specific anti-sense oligonucleotides knock down cancer
09-04-2007 · EurekAlert!
A new study in the September issue of the Journal of Clinical Investigation by Jeremy Graff and colleagues from Eli Lilly and Company demonstrates the anti-cancer effect of a new therapeutic (eIF4E-specific anti-sense oligonucleotides) in a mouse model of human tumors and has spawned clinical trials to test the ability of this therapeutic to treat human cancers.
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- Run amok enzyme causes same problems in both humans and fruit flies
12-18-2006 · EurekAlert!
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- Computer model mimics blink of a human eye
04-04-2007 · Massachusetts Institute of Technology (MIT)
MIT researchers report that a computer model designed to mimic the way the brain processes visual information performs as well as humans do on rapid categorization tasks.
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- DMP1 deletion cooperates with oncogenic K-ras in lung cancer
10-15-2007 · EurekAlert!
Scientists have identified the transcription factor DMP1 as a pivotal tumor suppressor for both human and mouse lung cancers, especially in carcinomas that exhibit intact Arf-p53 pathways. The research, published by Cell Press in the October 2007 issue of Cancer Cell, may lead to development of new drug therapies for lung cancer.
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- Curry-derived molecules might be too spicy for colorectal cancers
11-04-2007 · EurekAlert!
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- JCI table of contents: June 21, 2007
06-21-2007 · EurekAlert!
This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, June 21, 2007 including: A diet rich in omega-3 fatty acids may lower prostate cancer genetic risk; Mending a broken heart: How to boost the number and function of cardiac stem cells; Autophagy plays a role in heart's poor response to stress; New mouse model for the study of some forms of human hypertension; and others.
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- Mouse FH knockout resembles human renal cell cancer
04-09-2007 · EurekAlert!
A new mouse model is providing valuable insight into the biochemical pathways that are associated with development of renal cysts and renal cell cancer. The research, published in the April issue of the journal Cancer Cell, published by Cell Press, provides new information about the relationship between hypoxia and cancer progression. In addition, it is likely that this mouse model may prove to be a useful tool for testing therapeutic strategies for renal cell cancer.
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- Scientists follow familiar TRAIL to new cancer therapy
07-09-2007 · EurekAlert!
A new study identifies a combination therapy that may sensitize human cancer cells to a promising treatment currently being used in clinical trials. The research, published in the July issue of the journal Cancer Cell, published by Cell Press, provides a pharmacological method for enhancing the potency and effectiveness of a tumor necrosis factor death receptor ligand against a variety of human cancers.
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07-12-2007 · EurekAlert!
One of the major issues associated with longer life expectancy in man and his best friend is an increase in the incidence of cancer. Even though they cannot talk, it seems dogs might be able to tell us why and how certain cancers develop. In turn that could lead to better treatments for both canine and human cancer patients.
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- New weapon to fight leukemia
08-23-2007 · EurekAlert!
A new study indicates that the drug FTY720 prevents disease in a mouse model of two leukemias -- blast crisis chronic myeloid leukemia and acute lymphocytic leukemia -- caused by the cancer protein BCR-ABL. As the drug also induced cell lines from humans with these leukemias to die in vitro the authors suggest that FTY720 should be considered by researchers and clinicians developing new approaches to treat CML-BC and ALL.
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