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New gene found for Crohn's disease
10-26-2006 · EurekAlert!A new gene associated with Crohn's disease has been identified by a team of researchers. Interestingly, one of the mutations in the gene, which codes for a receptor in a major inflammatory pathway, appears to confer significant protection against the disease. The finding, the researchers report, points to a crucial target for drugs that might better manage both Crohn's and ulcerative colitis, which affect more than one million Americans.
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Keywords: gene, crohn, disease
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Similar news on "New gene found for Crohn's disease":
- Cedars-Sinai researchers on multicenter team linking gene mutation to Crohn's disease
10-26-2006 · EurekAlert!
The North American IBD Genetics Consortium has linked a gene mutation to the development of Crohn's disease, a chronic, relapsing inflammatory disorder of the gastrointestinal tract that affects 100 to 150 of every 100,000 people of European ancestry. The consortium is composed of IBD genetics research groups from seven centers in North America, including Cedars-Sinai Medical Center, and this effort was led by teams at Yale University and the University of Pittsburgh.
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- Il-22 gene delivers the goods and decreases intestinal inflammation
01-02-2008 · EurekAlert!
There are two major types of inflammatory bowel disease, Crohn disease and ulcerative colitis. Conflicting reports have indicated the soluble factor IL-22 can have both IBD promoting and IBD controlling effects. A new study has, however, now indicated that local delivery of the Il-22 gene ameliorates disease in a mouse model of UC, leading to the suggestion that individuals with UC might benefit from local delivery of the IL-22 gene to their intestines.
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- Researchers find gene linked to Crohn's disease
10-26-2006 · EurekAlert!
An international team of researchers has identified another gene mutation linked to the inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis. The team, including Johns Hopkins gastroenterologists and geneticists, says the novel mutation is in the interleukin-23 (IL-23) gene receptor present in healthy people without Crohn's disease but rare in those with the disease.
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- JCI table of contents: May 24, 2007
05-24-2007 · EurekAlert!
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, May 24, 2007, in the JCI, including: "Stuck on you: CEACAM6 helps E. coli stick to intestinal lining in Crohn's disease"; "PPARgamma is required for the full effect of antidiabetic drugs"; "Mind over liver: Resistin's action in brain linked to liver insulin resistance"; "Gene Gas1 is involved in severe craniofacial malformations"; and others.
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- Crohn's disease gene identified
10-26-2006 · EurekAlert!
Alterations in the receptor for a known inflammatory response pathway are strongly associated with Crohn's disease and ulcerative colitis, according to a report by a consortium of American and Canadian researchers in the Oct. 26 online edition of Science.
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- Scientists find major susceptibility gene for Crohn's disease
10-26-2006 · EurekAlert!
Researchers report the discovery of a new genetic link to Crohn's disease. Mutations of a gene, which codes for a receptor in a major inflammatory pathway, are strongly associated with Crohn's, they found. Surprisingly, one type of mutation appears to confer significant protection, prioritizing a crucial target for drugs that might better manage Crohn's disease and ulcerative colitis. More than 1 million Americans have Crohn's or colitis, known collectively as inflammatory bowel disease.
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- Scientists find gene target that may protect against Crohn's disease and ulcerative colitis
10-26-2006 · EurekAlert!
According to one of the Canadian principal investigators, director of the Laboratory in Genetics and Genomic Medicine of Inflammation at the Montreal Heart Institute, Dr. John D. Rioux, "This discovery may lead to a paradigm shift in our thinking from 'genetics of diseases to genetics of health,' particularly as concerns Crohn's disease and ulcerative colitis."
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- Gene identified for Crohn's disease in children
07-18-2007 · EurekAlert!
Pediatrics researchers have identified a gene variant that raises a child’s risk of Crohn's disease, a chronic and painful condition attributed to inflammation of the gastrointestinal tract. Because multiple genes interact with each other and with environmental factors in Crohn's disease, sorting out the roles of specific genes may better enable doctors to classify a patient's genetic profile and guide individualized treatment.
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- Research team identifies additional genetic risk factors for Crohn's disease
04-15-2007 · EurekAlert!
An international research team has identified several novel genetic variations associated with the risk of Crohn's disease. One of the identified genes establishes a role for autophagy, a previously unsuspected biological pathway, in Crohn's disease pathology, and the report documents functional studies which establish that this gene is integral to immune responses to intestinal bacteria.
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- Scientists find major susceptibility gene for Crohn's disease
04-15-2007 · EurekAlert!
Using a novel approach, researchers identified that the PHOX2B, NCF4 and ATG16L1 genes constitute genetic risk factors for Crohn's disease. In addition, their study identified two regions of the genome where genetic risk factors are located but no known genes were implicated -- further work will be necessary to identify the causal genes in these regions.
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