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Unintended consequences of cancer therapies

Radiation and chemotherapy can destroy a tumor, but they may also indirectly promote metastasis, the spread of cancerous cells to other organs.

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Keywords: unintended, consequences, cancer, therapies, consequence, therapy

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1. Epigenetic drugs, promising for breast cancer treatment
   12-20-2006 · EurekAlert!
   Worldwide, cancer persists as one of the most important diseases that affect the human being. The knowledge on the molecular bases of cancer generated during the last decades has been successfully translated into small but significant gains in overall cancer survival rates due to better primary prevention measures, improved diagnostic methods and the development of more effective and specific therapies, collectively termed "molecular targeted therapies." In the context of these new forms of treatment, epigenetic or transcriptional cancer therapy is clearly promising.
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2. Genes and biomarkers that allow doctors to choose the right therapy for the right patient
   04-17-2007 · EurekAlert!
   Genetic and epigenetic variations ensure that no two people are exactly alike, and the same holds true for any two cancers. Now, researchers have the tools and the knowledge to help predict how individuals will respond to cancer therapies, enabling them to create more effective therapies for individual cancers -- personalized medicine.
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3. Saving salivary glands from the collateral damage of radiation therapy
   10-27-2006 · EurekAlert!
   Researchers have shown that targeted overexpression of heat shock protein 25 prevents radiation-induced damage to salivary glands, a common consequence of treatment for head and neck cancer. The related report by Lee et al., "Radioprotective effect of HSP25 on submandibular glands of rats," appears in the November issue of the American Journal of Pathology.
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4. Research linking Ashkenazi Jews and breast cancer genes beset by problems
   11-01-2006 · EurekAlert!
   Genetic research over the past decade has linked Ashkenazi Jewish ethnicity to an increased risk for hereditary breast cancer, so much so that certain gene mutations have become known as "Jewish ancestral mutations." But a new study released in the November 2006 issue of the American Journal of Public Health challenges this population-based approach, warning that disparities in access to care and other unintended consequences for specific ethic groups can result, and may have already occurred.
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5. Taking Cancer's Fingerprint: Rapid genetic profiling for personalized therapy
   02-17-2007 · Science News Online
   A new, faster way to identify cancer-causing mutations in the DNA of tumor cells may pave the way for the next generation of custom-tailored cancer therapies.
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6. New biomarker predicts effectiveness of breast cancer drugs
   12-07-2006 · EurekAlert!
   University of Cincinnati researchers have identified a new way to predict when anti-estrogen drug therapies are inappropriate for patients with hormone-dependent breast cancer.Scientists say these findings could help physicians more accurately predict which tumors will respond to anti-estrogen therapy and improve long-term survival for breast cancer patients.
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7. Pre-treatment blood test could guide lung cancer therapy
   06-05-2007 · EurekAlert!
   A multi-center team, led by Vanderbilt-Ingram Cancer Center investigators, has developed a new pre-treatment blood test that predicts which non-small-cell lung cancer patients will live longer when they are treated with certain targeted cancer therapies (Iressa, Tarceva). The mass spectrometry-based test, described in the June 6 Journal of the National Cancer Institute, may allow physicians to select the most beneficial therapy for each lung cancer patient, a step forward in the era of personalized medicine.
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8. Whites take supplemental breast cancer therapy more often than blacks
   10-08-2007 · EurekAlert!
   A new study finds that white women more frequently take more of the life-prolonging supplemental therapies used to treat breast cancer than African-American women.
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9. First report that apoptotic and anti-angiogenic therapies work better together than alone
   11-10-2006 · EurekAlert!
   American researchers have found that giving a combination of imantanib and a drug that induces cell death was better at inhibiting the growth of Ewing's sarcoma in mice than either therapy on its own, according to research presented at the 18th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Prague on Friday.
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10. Nodal status is best predictor of outcome after neoadjuvant therapy for esophageal cancer
    07-13-2007 · EurekAlert!
    The number of lymph nodes that contain evidence of cancer is the best predictor of the effectiveness of adding chemotherapy and radiation to a treatment plan prior to surgery in individuals with esophageal cancer, according to a study published last month in the Annals of Surgery. The authors say their finding is particularly important because the focus of recent pathological studies of response to neoadjuvant therapies has been on the primary tumor rather than nodal sites.
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