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Scientists find major susceptibility gene for Crohn's disease
10-26-2006 · EurekAlert!Researchers report the discovery of a new genetic link to Crohn's disease. Mutations of a gene, which codes for a receptor in a major inflammatory pathway, are strongly associated with Crohn's, they found. Surprisingly, one type of mutation appears to confer significant protection, prioritizing a crucial target for drugs that might better manage Crohn's disease and ulcerative colitis. More than 1 million Americans have Crohn's or colitis, known collectively as inflammatory bowel disease.
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Keywords: scientists, major, susceptibility, gene, crohn, disease, scientist
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- Scientists find major susceptibility gene for Crohn's disease
04-15-2007 · EurekAlert!
Using a novel approach, researchers identified that the PHOX2B, NCF4 and ATG16L1 genes constitute genetic risk factors for Crohn's disease. In addition, their study identified two regions of the genome where genetic risk factors are located but no known genes were implicated -- further work will be necessary to identify the causal genes in these regions.
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- Scientists find major susceptibility genes for Crohn's disease
04-16-2007 · EurekAlert!
A consortium of Canadian and American researchers led by Dr. John D. Rioux, PhD, Associate Professor of Medicine at the Montreal Heart Institute and the Université de Montréal, report in the April 15 online edition of Nature Genetics the results from a search of the entire human genome for genetic risk factors leading to the development of Crohn's disease.
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10-26-2006 · EurekAlert!
A new gene associated with Crohn's disease has been identified by a team of researchers. Interestingly, one of the mutations in the gene, which codes for a receptor in a major inflammatory pathway, appears to confer significant protection against the disease. The finding, the researchers report, points to a crucial target for drugs that might better manage both Crohn's and ulcerative colitis, which affect more than one million Americans.
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10-26-2006 · EurekAlert!
According to one of the Canadian principal investigators, director of the Laboratory in Genetics and Genomic Medicine of Inflammation at the Montreal Heart Institute, Dr. John D. Rioux, "This discovery may lead to a paradigm shift in our thinking from 'genetics of diseases to genetics of health,' particularly as concerns Crohn's disease and ulcerative colitis."
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