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Scientists find gene target that may protect against Crohn's disease and ulcerative colitis
10-26-2006 · EurekAlert!According to one of the Canadian principal investigators, director of the Laboratory in Genetics and Genomic Medicine of Inflammation at the Montreal Heart Institute, Dr. John D. Rioux, "This discovery may lead to a paradigm shift in our thinking from 'genetics of diseases to genetics of health,' particularly as concerns Crohn's disease and ulcerative colitis."
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Keywords: scientists, gene, target, protect, crohn, disease, ulcerative, colitis, scientist, coliti
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10-26-2006 · EurekAlert!
Researchers report the discovery of a new genetic link to Crohn's disease. Mutations of a gene, which codes for a receptor in a major inflammatory pathway, are strongly associated with Crohn's, they found. Surprisingly, one type of mutation appears to confer significant protection, prioritizing a crucial target for drugs that might better manage Crohn's disease and ulcerative colitis. More than 1 million Americans have Crohn's or colitis, known collectively as inflammatory bowel disease.
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- New gene found for Crohn's disease
10-26-2006 · EurekAlert!
A new gene associated with Crohn's disease has been identified by a team of researchers. Interestingly, one of the mutations in the gene, which codes for a receptor in a major inflammatory pathway, appears to confer significant protection against the disease. The finding, the researchers report, points to a crucial target for drugs that might better manage both Crohn's and ulcerative colitis, which affect more than one million Americans.
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10-26-2006 · EurekAlert!
An international team of researchers has identified another gene mutation linked to the inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis. The team, including Johns Hopkins gastroenterologists and geneticists, says the novel mutation is in the interleukin-23 (IL-23) gene receptor present in healthy people without Crohn's disease but rare in those with the disease.
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- Il-22 gene delivers the goods and decreases intestinal inflammation
01-02-2008 · EurekAlert!
There are two major types of inflammatory bowel disease, Crohn disease and ulcerative colitis. Conflicting reports have indicated the soluble factor IL-22 can have both IBD promoting and IBD controlling effects. A new study has, however, now indicated that local delivery of the Il-22 gene ameliorates disease in a mouse model of UC, leading to the suggestion that individuals with UC might benefit from local delivery of the IL-22 gene to their intestines.
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Mobile DNA, which inserts foreign genes into target cells, is a powerful force in the march of evolution and the spread of disease. Working with the lambda virus and E. coli bacteria, Brown University biologists have solved the structure of a six-protein complex critical to performing this gene-grafting surgery. The technique they developed could be used to reveal the structure of other critical protein complexes, landing the work on the cover of Molecular Cell.
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04-15-2007 · EurekAlert!
Using a novel approach, researchers identified that the PHOX2B, NCF4 and ATG16L1 genes constitute genetic risk factors for Crohn's disease. In addition, their study identified two regions of the genome where genetic risk factors are located but no known genes were implicated -- further work will be necessary to identify the causal genes in these regions.
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- JCI table of contents: November 22, 2006
11-22-2006 · EurekAlert!
This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, November 22, 2006, in the JCI, including: Altered sodium channel function linked to heart failure, and Spot the difference: proteasome composition differs in Crohn disease and ulcerative colitis.
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10-11-2007 · EurekAlert!
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12-19-2006 · EurekAlert!
A new, large survey supported by the Crohn's & Colitis Foundation of America (CCFA) finds that 65 percent of ulcerative colitis patients are less than fully compliant with first-line therapies to treat their disease.The most commonly reported reasons for noncompliance with medications were the dosing frequency, the number of pills and the inconvenience associated with the medication.
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